Evidence map›Paper›PMID 31730286›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

Blood pressure control according to clinical practice guidelines is associated with decreased mortality and cardiovascular events among liver transplant recipients.

Lisa B VanWagner, Jane L Holl, Samantha Montag, Dyanna Gregory, Sean Connolly, Megan Kosirog, Patrick Campbell, Stewart Pine, Amna Daud, Dan Finn and 4 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Article
  6. Generalizability of kidney transplant data in electronic health records - The Epic Cosmos database vs the Scientific Registry of Transplant Recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Monitoring cardiovascular risk factors after liver transplantation may improve outcomes.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2022
    Article
  14. Blood Pressure Variability Early After Liver Transplantation Predicts Long-Term Mortality.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Current Concepts of Cirrhotic Cardiomyopathy.Clinics in liver disease · 2021
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Lisa B VanWagnerDepartment of Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0002-6264-2573
Jane L HollCenter for Healthcare Delivery Science and Innovation and Department of Neurology, Biological Sciences Division, University of Chicago, Chicago, Illinois.ORCID 0000-0002-2934-1672
Samantha MontagDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Dyanna GregoryDepartment of Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Sean ConnollyDepartment of Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Megan KosirogDepartment of Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Patrick CampbellDepartment of Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Stewart PineDepartment of Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Amna DaudComprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Dan FinnDepartment of Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Daniela LadnerComprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0001-5526-8272
Anton I SkaroDepartment of Surgery, Division of General Surgery and Multi-Organ Transplant, University of Western Ontario Schulich School of Medicine & Dentistry, London, Ontario, Canada.
Josh LevitskyDepartment of Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0001-7527-6093
Donald M Lloyd-JonesDepartment of Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0003-0847-6110
Northwestern University · USUniversity of Chicago · USWestern University · CA

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Implementation science to improve cardiovascular outcomes among liver transplant recipientsK23HL136891 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VANWAGNER, LISA B · 2017 to 2020
$757k
NCATS NIH HHS UL1 TR001422NHLBI NIH HHS K23 HL136891Northwestern University Clinical and Translational Sciences (NUCATS) Institute
6 · The paper itself

Abstract

Data for liver transplant recipients (LTRs) regarding the benefit of care concordant with clinical practice guidelines for management of blood pressure (BP) are sparse. This paper reports on clinician adherence with BP clinical practice guideline recommendations and whether BP control is associated with mortality and cardiovascular events (CVEs) among LTRs. We conducted a longitudinal cohort study of adult LTRs who survived to hospital discharge at a large tertiary care network between 2010 and 2016. The primary exposure was a BP of <140/<90 mm Hg within year 1 of LT. Among 602 LTRs (mean age 56.7 years, 64% men), 92% had hypertension and 38% had new onset hypertension. Less than 30% of LTRs achieved a BP of <140/<90 mm Hg over a mean of 43.2 months. In multivariable models, adjusted for key confounders, BP control post-LT compared with lack of control was associated with a significantly lower hazard of mortality (hazard ratio [HR] 0.48, 95% confidence interval [CI] 0.39, 0.87) and of CVEs (HR 0.65, 95% CI 0.43, 0.97). The association between BP control of <140/<90 mm Hg with improved survival and decreased CVEs in LTRs suggests that efforts to improve clinician adherence to BP clinical practice recommendations should be intensified.

Indexed as

Cardiovascular DiseasesHypertensionLiver TransplantationAdultBlood PressureFemaleHumansLongitudinal StudiesMaleMiddle Agedcardiovascular diseaseclinical research/practicehealth services and outcomes researchhypertension/antihypertensivesliver transplantation/hepatology

Identifiers

PMID31730286
PMCPMC7042060
OpenAlexW2986328223

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.