Evidence map›Paper›PMID 31730278›Full record

ArticlePhotochemistry and photobiology2020

Synthesis and Characterization of Ru(II) Complexes with π-Expansive Imidazophen Ligands for the Photokilling of Human Melanoma Cells.

Goutam Ghosh, Huimin Yin, Susan M A Monro, Tariq Sainuddin, Lloyd Lapoot, Alexander Greer, Sherri A McFarland

Open access · greenAbstract read
In one paragraph

Article in Photochemistry and photobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Goutam GhoshDepartment of Chemistry, Acadia University, Wolfville, NS, Canada.
Huimin YinDepartment of Chemistry, Acadia University, Wolfville, NS, Canada.
Susan M A MonroDepartment of Chemistry, Acadia University, Wolfville, NS, Canada.
Tariq SainuddinDepartment of Chemistry, Acadia University, Wolfville, NS, Canada.
Lloyd LapootDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY.
Alexander GreerDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY.ORCID 0000-0003-4444-9099
Sherri A McFarlandDepartment of Chemistry, Acadia University, Wolfville, NS, Canada.ORCID 0000-0002-8028-5055
Acadia University · CAThe Graduate Center, CUNY · USCity University of New York · USUniversity of North Carolina at Greensboro · US

Funding

Immunomodulating Ruthenium Metal Complexes for Melanoma PhotodynamicTherapyR01CA222227 · NCI · UNIVERSITY OF TEXAS ARLINGTON · PI GUJAR, SHASHI, MCFARLAND, SHERRI · 2018 to 2022
$2.6M
CIHRNCI NIH HHS R01 CA222227
6 · The paper itself

Abstract

Ru(II) complexes were synthesized with π-expanding (phenyl, fluorenyl, phenanthrenyl, naphthalen-1-yl, naphthalene-2-yl, anthryl and pyrenyl groups) attached at a 1H-imidazo[4,5-f][1,10]phenanthroline ligand and 4,4'-dimethyl-2,2'-bipyridine (4,4'-dmb) coligands. These Ru(II) complexes were characterized by 1D and 2D NMR, and mass spectroscopy, and studied for visible light and dark toxicity to human malignant melanoma SK-MEL-28 cells. In the SK-MEL-28 cells, the Ru(II) complexes are highly phototoxic (EC

Indexed as

Cell Line, TumorCoordination ComplexesHumansLigandsMelanomaPhenanthrolinesPhotochemotherapyPhotosensitizing AgentsRuthenium CompoundsSkin Neoplasms1,10-phenanthrolineCoordination ComplexesLigandsPhenanthrolinesPhotosensitizing AgentsRuthenium Compounds

Identifiers

PMID31730278
PMCPMC7138724
OpenAlexW2988638361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.