ArticleNeuromodulation : journal of the International Neuromodulation Society2020
Effectiveness and Safety of Dorsal Root Ganglion Stimulation for the Treatment of Chronic Pain: A Pooled Analysis.
Article in Neuromodulation : journal of the International Neuromodulation Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07170722 (Efficacy of Sub-Threshold Dorsal Root Ganglion), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Sub-Threshold Dorsal Root Ganglion (DRG) Stimulation Versus Sham in Established Responders: A Randomised, Double-Blind, Two-Period Crossover Trial
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Continuous electrical stimulation of the dorsal root ganglion (drg-s) as a salvation therapy in patients previously treated with spinal cord stimulation. systematic review and pooled analysis.Neurosurgical review · 2025Pooled it
- Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 5th Edition.Pain medicine (Malden, Mass.) · 2022Guideline
- Management of Neuropathic Pain in Complex Regional Pain Syndrome: A Comprehensive Review.Pain practice : the official journal of World Institute of Pain · 2026Review
- The Leiden-Nice Consensus (2024-2025)-Technical Standardization and Clinical Algorithms for Pulsed Radiofrequency for Chronic Pain.Pain and therapy · 2026Review
- Integrating dorsal root ganglion stimulation with transforaminal lumbar interbody fusion: proof of concept study.North American Spine Society journal · 2026Article
- Therapy-specific motoneuron activation with epidural and dorsal root ganglion stimulation in spinal cord injury.Journal of neurophysiology · 2026Article
- Review of Physiology, Pathology, and Pharmacology of Voltage-Gated Sodium Channels in Regards to the Potential Role of NaV 1.8 Selective Inhibitor, Suzetrigine, for Chronic Pain Management.Journal of pain research · 2026Review
- 14. Discogenic Low Back Pain.Pain practice : the official journal of World Institute of Pain · 2025Review
- Dorsal Root Ganglion Stimulation in Patients With Refractory Abdominal Pain: A Case Series.Cureus · 2025Article
- 16. Pain in chronic pancreatitis.Pain practice : the official journal of World Institute of Pain · 2025Review
- Overcoming failure: improving acceptance and success of implanted neural interfaces.Bioelectronic medicine · 2025Review
- Rates and Causes of Reoperations Following Spinal Cord Stimulation Within a 2-12 year Period.Global spine journal · 2025Article
- Neuromodulation guide for the non-neuromodulator clinician: What it is and how it can benefit patients?Biomolecules & biomedicine · 2025Review
- Dermatologic manifestations of complex regional pain syndrome improved after dorsal root ganglion stimulation.Surgical neurology international · 2025Article
- 10. Complex regional pain syndrome.Pain practice : the official journal of World Institute of Pain · 2025Review
- Computational modeling of dorsal root ganglion stimulation using an Injectrode.Journal of neural engineering · 2024Article
- Unveiling the Gut-Disc Axis: How Microbiome Dysbiosis Accelerates Intervertebral Disc Degeneration.Journal of inflammation research · 2024Review
- Blocking Aδ- and C-fiber neural transmission by sub-kilohertz peripheral nerve stimulation.Frontiers in neuroscience · 2024Article
- Clinical Diagnosis and Treatment of Chronic Pain.Diagnostics (Basel, Switzerland) · 2023Review
- Current Neurostimulation Therapies for Chronic Pain Conditions.Current pain and headache reports · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSince it became available in the mid-2010s, dorsal root ganglion (DRG) stimulation has become part of the armamentarium to treat chronic pain. To date, one randomized controlled trial, and several studies of moderate sample size and various etiologies have been published on this topic. We conducted a pooled analysis to investigate the generalizability of individual studies and to identify differences in outcome between chronic pain etiologic subgroups and/or pain location. MATERIALS AND
methodsOne prospective, randomized comparative trial and six prospective, single-arm, observational studies were identified that met pre-defined acceptance criteria. Pain scores and patient-reported outcome (PRO) measures were weighted by study sample sizes and pooled. Safety data are reported in aggregate form.
resultsOur analysis included 217 patients with a permanent implant at 12-month follow-up. Analysis of pooled data showed an overall weighted mean pain score of 3.4, with 63% of patients reporting ≥50% pain relief. Effectiveness sub-analyses in CRPS-I, causalgia, and back pain resulted in a mean reduction in pain intensity of 4.9, 4.6, and 3.9 points, respectively. Our pooled analysis showed a pain score for primary affected region ranging from 1.7 (groin) to 3.0 (buttocks) and responder rates of 80% for foot and groin, 75% for leg, and 70% for back. A substantial improvement in all PROs was observed at 12 months. The most commonly reported procedural or device complications were pain at the IPG pocket site, lead fracture, lead migration, and infection.
conclusionsDRG stimulation is an effective and safe therapy for various etiologies of chronic pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.