ArticleThe British journal of dermatology2020
Associations of eczema phenotypes with emotional and behavioural problems from birth until school age. The Generation R Study.
Article in The British journal of dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Psychosocial interventions for children with dermatological conditions: systematic review and meta-analysis.Journal of pediatric psychology · 2025Pooled it
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Perinatal Risk Factors, Allergic Conditions and Psychosocial Problems in Children and Adolescents with Mental Health Problems.Research on child and adolescent psychopathology · 2026Article
- Exploring syndemic vulnerability among adolescents living in urban cities in the Netherlands: a latent class analysis.BMJ public health · 2026Article
- Association of atopic dermatitis with emotional and behavioral problems in childhood.Journal of the American Academy of Dermatology · 2024Article
- Atopic dermatitis and risk of major neuropsychiatric disorders in children: A population-based cohort study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2023Article
- Associations between T cells and attention problems in the general pediatric population: The Generation R study.JCPP advances · 2021Article
- Association between nasal and nasopharyngeal bacterial colonization in early life and eczema phenotypes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- The Role of the Environment and Exposome in Atopic Dermatitis.Current treatment options in allergy · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEczema phenotypes and emotional and behavioural problems are highly prevalent in childhood, but their mutual relationship is not fully clear.
objectivesTo examine the associations of eczema phenotypes with school-age emotional and behavioural problems, and the bidirectional associations of eczema and emotional and behavioural problems from birth until 10 years.
methodsThis study among 5265 individuals was embedded in a prospective population-based cohort study. Never, early transient, mid-transient, late transient and persistent eczema phenotypes were identified based on parent-reported, physician-diagnosed eczema from age 6 months until 10 years. Emotional (internalizing) and behavioural (externalizing) problems were measured repeatedly using the Child Behavior Checklist from age 1·5 to 10 years. Cross-lagged models were applied for bidirectional analyses.
resultsAll eczema phenotypes were associated with more internalizing problems and attention problems at age 10 years, compared with never having eczema: range of Z-score differences 0·14 [95% confidence interval (CI) 0·01-0·27] to 0·39 (95% CI 0·18-0·60). Children with early transient eczema had more aggressive behaviour symptoms at age 10 years (Z = 0·16, 95% CI 0·05-0·27). Bidirectional analysis showed that eczema at 0-2 years was associated with more internalizing and externalizing problems at ages 3-6 and 10 years, while, inversely, only internalizing problems at 0-2 years were associated with an increased risk of eczema at age 10 years.
conclusionsEczema phenotypes are very modestly associated with more somatic symptoms and attention problems at school age. Early transient eczema is associated with more aggressive behaviour symptoms. Directional effects seem to occur from early-life eczema to later-life internalizing and externalizing problems, rather than the reverse.
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