ArticleGenome biology and evolution2019
Alien Domains Shaped the Modular Structure of Plant NLR Proteins.
Article in Genome biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Accelerating Resistance Breeding: Emerging Methods to Identify and Validate Plant Immunity Genes.Plants (Basel, Switzerland) · 2026Review
- PharaohFUN: phylogenomic analysis for plant protein history and function elucidation.Molecular biology and evolution · 2026Article
- Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026Review
- The Landscape of Integrated Domains of Angiosperm NLR Genes Reveals Continuous Architecture Evolution of Plant Intracellular Immune Receptors.Plants (Basel, Switzerland) · 2025Article
- Genomic organization, domain assortments, and nucleotide-binding domain diversity of NLR proteins in Sordariales fungi.PLoS genetics · 2025Article
- PRGminer: harnessing deep learning for the prediction of resistance genes involved in plant defense mechanisms.Frontiers in plant science · 2025Article
- The N-terminal domains of NLR immune receptors exhibit structural and functional similarities across divergent plant lineages.The Plant cell · 2024Article
- A comprehensive review of soybean RNL and TIR domain proteins.Plant molecular biology · 2024Review
- NLR receptors in plant immunity: making sense of the alphabet soup.EMBO reports · 2023Review
- Taking the lead: NLR immune receptor N-terminal domains execute plant immune responses.The New phytologist · 2023Review
- NLR immune receptors: structure and function in plant disease resistance.Biochemical Society transactions · 2023Review
- NLRscape: an atlas of plant NLR proteins.Nucleic acids research · 2023Article
- PlantNLRatlas: a comprehensive dataset of full- and partial-length NLR resistance genes across 100 chromosome-level plant genomes.Frontiers in plant science · 2023Article
- NB-LRR Lineage-Specific Equipment Is Sorted Out by Sequence Pattern Adaptation and Domain Segment Shuffling.International journal of molecular sciences · 2022Article
- Prediction of NB-LRR resistance genes based on full-length sequence homology.The Plant journal : for cell and molecular biology · 2022Article
- Transcriptomic and genomic analysis provides new insights in molecular and genetic processes involved in zucchini ZYMV tolerance.BMC genomics · 2022Article
- Article
- NLRexpress-A bundle of machine learning motif predictors-Reveals motif stability underlying plant Nod-like receptors diversity.Frontiers in plant science · 2022Article
- Multilevel evolution shapes the function of NB-LRR encoding genes in plant innate immunity.Frontiers in plant science · 2022Review
- RefPlantNLR is a comprehensive collection of experimentally validated plant disease resistance proteins from the NLR family.PLoS biology · 2021Article
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Authors and funding
8 authors.
Funding
Abstract
Plant innate immunity mostly relies on nucleotide-binding (NB) and leucine-rich repeat (LRR) intracellular receptors to detect pathogen-derived molecules and to induce defense responses. A multitaxa reconstruction of NB-domain associations allowed us to identify the first NB-LRR arrangement in the Chlorophyta division of the Viridiplantae. Our analysis points out that the basic NOD-like receptor (NLR) unit emerged in Chlorophytes by horizontal transfer and its diversification started from Toll/interleukin receptor-NB-LRR members. The operon-based genomic structure of Chromochloris zofingiensis NLR copies suggests a functional origin of NLR clusters. Moreover, the transmembrane signatures of NLR proteins in the unicellular alga C. zofingiensis support the hypothesis that the NLR-based immunity system of plants derives from a cell-surface surveillance system. Taken together, our findings suggest that NLRs originated in unicellular algae and may have a common origin with cell-surface LRR receptors.
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