ArticleClinical epigenetics2019
Epigenetic age acceleration and metabolic syndrome in the coronary artery risk development in young adults study.
Article in Clinical epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 87 citations in OpenAlex.
- Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health.Circulation research · 2021Trial
- Epigenetic age acceleration and metabolic syndrome among Hispanic/Latino adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL).International journal of obesity (2005) · 2026Article
- The mediating role of biological age acceleration in the associations between lifestyle factors and incident digestive system cancers: A Prospective Cohort Study from the UK Biobank.The journal of nutrition, health & aging · 2026Article
- Inter-organ communication shapes human metabolic tissue states and resolves anti-diabetic drug response modes in a six-tissue microphysiological system.bioRxiv : the preprint server for biology · 2026Article
- The association of time-restricted eating and indices of organ-specific aging in relation to metabolic health and obesity.NPJ science of food · 2026Article
- Epigenetic age acceleration in young adults with congenital heart disease.Clinical epigenetics · 2026Article
- Interpretable Prediction of Late-Stage CKM Syndrome Association From Dietary Nutrients in Accelerated Aging Using SHAP and LIME.Food science & nutrition · 2026Article
- Trajectories of cardiovascular ageing-from molecular mechanisms to clinical implementation.Cardiovascular research · 2025Review
- Metabolic dysfunction over a life course key to healthy ageing inequality.Aging clinical and experimental research · 2025Review
- Three generations of epigenetic clocks in mediating the adverse effect of smoking on metabolic health.Epigenomics · 2025Article
- Cross-sectional and longitudinal association of seven DNAm-based predictors with metabolic syndrome and type 2 diabetes.Clinical epigenetics · 2025Article
- Article
- Maximizing insights from longitudinal epigenetic age data: simulations, applications, and practical guidance.Clinical epigenetics · 2024Article
- The fetal origins of metabolic health: exploring the association between newborn biological age and metabolism hormones in childhood.BMC medicine · 2024Article
- DNA methylation age acceleration contributes to the development and prediction of non-alcoholic fatty liver disease.GeroScience · 2024Article
- Investigating the Relationship between Epigenetic Age and Cardiovascular Risk in a Population with Overweight/Obesity.Biomedicines · 2024Article
- Maximizing Insights from Longitudinal Epigenetic Age Data: Simulations, Applications, and Practical Guidance.Research square · 2024Article
- Metabolic syndrome and epigenetic aging: a twin study.International journal of obesity (2005) · 2024Article
- A Comparison of 5 Measures of Accelerated Biological Aging and Their Association With Incident Cardiovascular Disease: The CARDIA Study.Journal of the American Heart Association · 2024Article
- Article
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Authors and funding
18 authors at 7 institutions in 1 country.
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Abstract
backgroundThe metabolic syndrome (MetS) is a collection of metabolic disturbances that can lead to various cardiovascular diseases. Previous studies have shown a more adverse metabolic risk profile is associated with more advanced biological aging. The associations between epigenetic biomarkers of age with MetS, however, are not well understood. We therefore investigated the associations between epigenetic age acceleration and MetS severity score and incident MetS.
resultsA subset of study participants with available whole blood at examination years 15 and 20 from the Coronary Artery Risk Development in Young Adults Study underwent epigenomic profiling using the Illumina MethylationEPIC Beadchip (~ 850,000 sites). Intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA) were calculated from DNA methylation levels. The MetS severity score was positively associated with IEAA at years 15 (P = 0.016) and 20 (P = 0.016) and EEAA at year 20 (P = 0.040) in cross-sectional analysis. IEAA at year 20 was significantly associated with incident MetS at year 30 (OR = 1.05 [95% CI 1.01, 1.10], P = 0.028).
conclusionsTo our knowledge, this is the first report of the longitudinal association between epigenetic age acceleration and MetS. These findings suggest that a higher MetS severity score is associated with accelerated epigenetic aging and such aging may play a role in the development of metabolic disorders, potentially serving as a useful biomarker of and early detection tool for future MetS.
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