Evidence map›Paper›PMID 31730016›Full record

ArticleBMC research notes2019

Exploring the immunomodulatory role of depot medroxyprogesterones acetate and endogenous progesterone levels in HIV infected and uninfected women.

Nonzwakazi Mnqonywa, Nathlee Abbai, Viswanath Ragupathy, Gita Ramjee, Indira Hewlett, Dhayendre Moodley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Nonzwakazi MnqonywaHIV Prevention Research Unit, Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban, 3630, South Africa.
Nathlee AbbaiSchool of Clinical Medicine Research Laboratory, University of KwaZulu-Natal, 719 Umbilo Road, Congella, 4013, South Africa. abbain@ukzn.ac.za.ORCID http://orcid.org/0000-0003-2392-0574
Viswanath RagupathyCenter for Biologics Evaluation and Research, Food and Drug Administration, Building 72, 10933 New Hampshire Ave, Silver Spring, MD, 20892, USA.
Gita RamjeeHIV Prevention Research Unit, Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban, 3630, South Africa.
Indira HewlettCenter for Biologics Evaluation and Research, Food and Drug Administration, Building 72, 10933 New Hampshire Ave, Silver Spring, MD, 20892, USA.
Dhayendre MoodleyWomen's Health and HIV Research Unit, Department of Obstetrics and Gynaecology, School of Clinical Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Congella, 4013, South Africa.
Center for Biologics Evaluation and Research · USSouth African Medical Research Council · ZAUniversity of KwaZulu-Natal · ZA

Funding

Office of Women's Health -
6 · The paper itself

Abstract

objectiveThe aim of this proof of concept study was to determine the effect of depot medroxyprogesterone acetate on host and viral factors in HIV infected and uninfected women.

resultsIn this study, the gene expression levels for CCL5, CCR5 and CXCR4 was significantly higher in HIV positive women when compared to HIV negative women (p < 0.05). An upregulation of CCR5 and CXCR4 was evident in less than 20% of the HIV infected women and none of the HIV uninfected women. The mean fold change for CCL3 was much higher in HIV uninfected when compared to infected women with a borderline significance (p = 0.062). In HIV uninfected women, the mean fold change in CCL3, CCL4, and CCL5 gene expression was not statistically different between women on DMPA versus women not on hormonal contraception. The proportion of women with an upregulation of CCL4 and CCR5 was higher in HIV infected women on DMPA. There was no association between endogenous progesterone level and chemokines and the HIV-1 receptors. The gene expression levels in the chemokine receptors CCR5 and CXCR4 were significantly higher in the HIV infected women when compared to the women who remained HIV uninfected.

Indexed as

AdultChemokine CCL3Chemokine CCL4Chemokine CCL5Contraceptive Agents, FemaleContraceptive Agents, HormonalCross-Sectional StudiesFemaleGene Expression RegulationHIV-1HIV InfectionsHumansImmunomodulationMedroxyprogesterone AcetateProgesteroneProof of Concept StudyCCL3 protein, humanCCL4 protein, humanCCL5 protein, humanCCR5 protein, humanChemokine CCL3Chemokine CCL4Chemokine CCL5Contraceptive Agents, FemaleContraceptive Agents, HormonalCXCR4 protein, humanMedroxyprogesterone AcetateProgesteroneReceptors, CCR5Receptors, CXCR4Chemokine receptor type 5 (CCR5)Depot medroxyprogesterone acetate (DMPA)Endogenous progesteroneGene expressionHuman immunodeficiency virus (HIV)Immunomodulatory

Identifiers

PMID31730016
PMCPMC6857346
OpenAlexW2983366093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.