Evidence map›Paper›PMID 31729981›Full record

ArticleJournal of neuroinflammation2019

Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE).

Timothy N Friedman, Muhammad Saad Yousuf, Ana Catuneanu, Mansi Desai, Camille A Juźwik, Alyson E Fournier, Bradley J Kerr

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Timothy N FriedmanNeuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada.
Muhammad Saad YousufNeuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada.
Ana CatuneanuDepartment of Pharmacology, University of Alberta, Edmonton, Alberta, T6E 2H7, Canada.
Mansi DesaiDepartment of Pharmacology, University of Alberta, Edmonton, Alberta, T6E 2H7, Canada.
Camille A JuźwikMontreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada.
Alyson E FournierMontreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada.
Bradley J KerrNeuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada. bradley.kerr@ualberta.ca.ORCID http://orcid.org/0000-0002-0264-8316
University of Alberta · CAMontreal Neurological Institute and Hospital · CA

Funding

Multiple Sclerosis Society of Canada EGID2954
6 · The paper itself

Abstract

backgroundMultiple sclerosis is an autoimmune disease with a distinct female bias, as well as a high prevalence of neuropathic pain in both sexes. The dorsal root ganglia (DRG) contain the primary sensory neurons that give rise to pain, and damage to these neurons may lead to neuropathic pain. Here, we investigate the sex differences of the DRG transcriptome in a mouse model of MS.

methodsNext-generation sequencing was used to establish RNA and microRNA profiles from the DRG of mice with MOG

resultsThree thousand five hundred twenty genes and 29 microRNAs were differentially expressed in the DRG of female mice with MOG

conclusionsThis study provides evidence that females are uniquely affected by MOG

Indexed as

Sex CharacteristicsTranscriptomeAnimalsEncephalomyelitis, Autoimmune, ExperimentalFemaleGanglia, SpinalMaleMiceMice, Inbred C57BLMicroRNAsMicroRNAsDRGInflammationMicro-RNAMultiple sclerosisPain

Identifiers

PMID31729981
PMCPMC6858636
OpenAlexW2983048701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.