Evidence map›Paper›PMID 31729897›Full record

ArticleJournal of feline medicine and surgery2020

Feline coronavirus with and without spike gene mutations detected by real-time RT-PCRs in cats with feline infectious peritonitis.

Laura Emmler, Sandra Felten, Kaspar Matiasek, Hans-Joerg Balzer, Nikola Pantchev, Christian Leutenegger, Katrin Hartmann

Open access · bronzeAbstract read
In one paragraph

Article in Journal of feline medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Laura EmmlerClinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, Munich, Germany.ORCID 0000-0002-9085-8945
Sandra FeltenClinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, Munich, Germany.
Kaspar MatiasekSection of Clinical and Comparative Neuropathology, Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, Munich, Germany.
Hans-Joerg BalzerIDEXX Laboratories, Ludwigsburg, Germany.
Nikola PantchevIDEXX Laboratories, Ludwigsburg, Germany.
Christian LeuteneggerIDEXX Laboratories, West Sacramento, CA, USA.
Katrin HartmannClinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, Munich, Germany.
Ludwig-Maximilians-Universität München · DEIDEXX Laboratories (Germany) · DEIDEXX Laboratories (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesFeline infectious peritonitis (FIP) emerges when feline coronaviruses (FCoVs) mutate within their host to a highly virulent biotype and the immune response is not able to control the infection. FCoV spike (

methodsFine-needle aspirates (FNAs) and incisional biopsies (IBs) of popliteal and mesenteric lymph nodes, liver, spleen, omentum and kidneys (each n = 20), EDTA blood (n = 13), buffy coat smears (n = 13), serum (n = 11), effusion (n = 14), cerebrospinal fluid (n = 16), aqueous humour (n = 20) and peritoneal lavage (n = 6) were obtained from 20 cats with FIP diagnosed by immunohistochemistry. Samples were examined by RT-PCR targeting the FCoV

resultsIn 20/20 cats, FCoV with CONCLUSIONS AND RELEVANCE: In these 20 cats with FIP, FCoVs with

Indexed as

AnimalsBiopsy, Fine-NeedleCatsCoronavirus, FelineFeline Infectious PeritonitisFemaleImmunohistochemistryLymph NodesMaleMutationProspective StudiesReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionSpike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirusspike protein, Feline CoronavirusFCoVFIPIHCimmunohistochemistryRT-PCRS gene

Identifiers

PMID31729897
PMCPMC7206566
OpenAlexW2985430959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.