Evidence map›Paper›PMID 31729789›Full record

ArticleBipolar disorders2020

Network analysis of mood symptoms in adolescents with or at high risk for bipolar disorder.

Marc J Weintraub, Christopher D Schneck, David J Miklowitz

Open access · bronzeAbstract read
In one paragraph

Article in Bipolar disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 41 citations in OpenAlex.

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  15. A network structure of manic symptoms.Brain and behavior · 2021
    Article
  16. Phenotype Network and Brain Structural Covariance Network of Major Depression.Advances in experimental medicine and biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Marc J WeintraubJane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.ORCID 0000-0001-8724-120X
Christopher D SchneckDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
David J MiklowitzJane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy TrialR01MH123575 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, MIKLOWITZ, DAVID JAY · 2020 to 2023
$5.4M
1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
2/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093666 · NIMH · STANFORD UNIVERSITY · PI HARDAN, ANTONIO · 2012 to 2016
$2.0M
Family-Focused Treatment for Bipolar AdolescentsR01MH073817 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AXELSON, DAVID A · 2006 to 2010
$1.7M
Family-Focused Treatment for Bipolar AdolescentsR01MH073871 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2006 to 2010
$1.7M
Family-Focused Treatment for Bipolar AdolescentsR01MH074033 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI KOWATCH, ROBERT ANTHONY · 2006 to 2010
$1.3M
Technology-Enhanced Family-Focused Treatment for Adolescents at High Risk for Mood DisordersR34MH117200 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AREVIAN, ARMEN C, MIKLOWITZ, DAVID JAY · 2018 to 2020
$933k
Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar DisorderR34MH077856 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2007 to 2009
$638k
NIMH NIH HHS R01 MH073817NIMH NIH HHS R01 MH073871NIMH NIH HHS R01 MH074033NIMH NIH HHS R01 MH093666NIMH NIH HHS R01 MH093676NIMH NIH HHS R01 MH123575NIMH NIH HHS R34 MH077856NIMH NIH HHS R34 MH117200
6 · The paper itself

Abstract

objectivesNetwork analyses of psychopathology examine the relationships between individual symptoms in an attempt to establish the causal interactions between symptoms that may give rise to episodes of psychiatric disorders. We conducted a network analysis of mood symptoms in adolescents with or at risk for bipolar spectrum disorders.

methodsThe sample consisted of 272 treatment-seeking adolescents with or at high risk for bipolar disorder who had at least subsyndromal depressive or (hypo)manic symptoms. Based on symptom scores assessed via semi-structured interviews, we constructed the network of depressive and manic symptoms and identified the most central symptoms and symptom communities within the network. We used bootstrapping analyses to determine the reliability of network parameters.

resultsSymptoms within the depressive and manic mood poles were more related to each other than to symptoms of the opposing mood pole. Four communities were identified, including a depressive symptom community and three manic symptom communities. Fatigue and depressed mood were the strongest individual symptoms within the overall network (ie the most highly correlated with other symptoms), followed by motor hyperactivity. Mood lability and irritability were found to be "bridge" symptoms that connected the two mood poles.

conclusionsSymptoms of activity/energy (ie fatigue and hyperactivity) and depressed mood are the most prominent mood symptoms among youth with bipolar spectrum disorders. Mood lability and irritability represent potential warning signs of emergent episodes of either polarity. Targeting these central and bridge symptoms would lead to more efficient assessments and therapeutic interventions for bipolar disorder.

Indexed as

AffectAdolescentBipolar DisorderFemaleHumansIrritable MoodMalePsychomotor AgitationReproducibility of Resultsbootstrapcentralitydepressionmaniapediatricstrength

Identifiers

PMID31729789
PMCPMC7085972
OpenAlexW2987115618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.