Evidence map›Paper›PMID 31729777›Full record

ArticleBrain pathology (Zurich, Switzerland)2020

Reduction in the neuronal surface of post and presynaptic GABA

Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruíz, Ana Esther Moreno-Martínez, Luis de la Ossa, José Martínez-Hernández, Alain Buisson, Simon Früh, Bernhard Bettler, Ryuichi Shigemoto and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Review
  3. GABAeNeuro · 2026
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  5. G protein-gated inwardly rectifying KHistology and histopathology · 2025
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  6. Nanoarchitecture of CaBrain pathology (Zurich, Switzerland) · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. N-acetyltransferase 10 mediates cognitive dysfunction through the acetylation of GABAProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Regulation of Hippocamposeptal Synaptic Transmission by GABAJournal of molecular neuroscience : MN · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Nanoscale alterations in GABAAlzheimer's research & therapy · 2022
    Article
  19. Article
  20. GABACurrent topics in behavioral neurosciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 5 countries.

Alejandro Martín-BelmonteSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/ Almansa 14, 02008, Albacete, Spain.
Carolina AguadoSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/ Almansa 14, 02008, Albacete, Spain.
Rocío Alfaro-RuízSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/ Almansa 14, 02008, Albacete, Spain.
Ana Esther Moreno-MartínezSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/ Almansa 14, 02008, Albacete, Spain.
Luis de la OssaDepartamento de Sistemas Informáticos, Escuela Superior de Ingeniería Informática, Universidad de Castilla-La Mancha, 02071, Albacete, Spain.
José Martínez-HernándezSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/ Almansa 14, 02008, Albacete, Spain.
Alain BuissonGrenoble Institut des Neurosciences, Université Grenoble Alpes, BP 170, Grenoble, France.
Simon FrühDepartment of Biomedicine, Institute of Physiology, University of Basel, Basel, Switzerland.
Bernhard BettlerDepartment of Biomedicine, Institute of Physiology, University of Basel, Basel, Switzerland.
Ryuichi ShigemotoInstitute of Science and Technology (IST Austria), Am Campus 1, A-3400, Klosterneuburg, Austria.
Yugo FukazawaDivision of Brain Structure and Function, Faculty of Medical Science, University of Fukui, Fukui, Japan.
Rafael LujánSynaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/ Almansa 14, 02008, Albacete, Spain.ORCID 0000-0003-2001-9545
University of Castilla-La Mancha · ESUniversity of Basel · CHGrenoble Institute of Neurosciences · FRInstitute of Science and Technology Austria · ATUniversity of Fukui · JP

Funding

Horizon 2020 Framework Programme 720270Horizon 2020 Framework Programme 785907Junta de Comunidades de Castilla-La Mancha RTI2018-095812-B-I00Ministerio de Economía y Competitividad BFU2015-63769-RUniversity of Fukui 16H04662University of Fukui 17K19446University of Fukui 18H05120
6 · The paper itself

Abstract

The hippocampus plays key roles in learning and memory and is a main target of Alzheimer's disease (AD), which causes progressive memory impairments. Despite numerous investigations about the processes required for the normal hippocampal functions, the neurotransmitter receptors involved in the synaptic deficits by which AD disables the hippocampus are not yet characterized. By combining histoblots, western blots, immunohistochemistry and high-resolution immunoelectron microscopic methods for GABA

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsCell MembraneDisease Models, Animalgamma-Aminobutyric AcidHippocampusMiceMice, TransgenicNeuronsPresenilin-1Receptors, GABA-BSynapsesSynaptic TransmissionAmyloid beta-Protein Precursorgamma-Aminobutyric AcidPresenilin-1Receptors, GABA-BAlzheimer's diseaseelectron microscopyfreeze-fractureGABAB receptorshippocampusimmunohistochemistryion channels

Identifiers

PMID31729777
PMCPMC7317930
OpenAlexW2985981649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.