Observational studyJournal of nephrology2020
Validation by CT scan of quadriceps muscle thickness measurement by ultrasound in acute kidney injury.
Observational study in Journal of nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evaluation of Appendicular Muscle Mass in Sarcopenia in Older Adults Using Ultrasonography: A Systematic Review and Meta-Analysis.Gerontology · 2022Pooled it
- Protein-Energy Wasting Assessment and Clinical Outcomes in Patients with Acute Kidney Injury: A Systematic Review with Meta-Analysis.Nutrients · 2020Pooled it
- Ultrasound quadriceps muscle thickness is variably associated with frailty in haemodialysis recipients.BMC nephrology · 2023Trial
- Characterization of the Ideal Speed of Sound for Plantar Soft Tissue Using Quasi-Simultaneous Ultrasound and Computed Tomography in Cadaveric Feet.Annals of biomedical engineering · 2026Article
- Does closed suction drainage reduce postoperative hematoma and muscle swelling after total hip arthroplasty? A retrospective comparative study using computed tomography.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Article
- Appropriate needle insertion depth for trigger point injections of the parascapular region.Turkish journal of physical medicine and rehabilitation · 2026Article
- Practical Guide to Nutritional Assessment in CKD: Current Tools, Emerging Technologies, and Future Directions.Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Morphofunctional Assessment of Malnutrition and Sarcopenia Using Nutritional Ultrasonography in Patients Undergoing Maintenance Hemodialysis.Medicina (Kaunas, Lithuania) · 2025Article
- Sarcopenia diagnosed by ultrasound-assessed quadriceps muscle thickness and handgrip strength predicts mortality in patients on hemodialysis.Journal of nephrology · 2024Article
- Clinical practice guidelines for nutritional assessment and monitoring of adult ICU patients in China.Journal of intensive medicine · 2024Article
- Making the invisible visible: imaging techniques for assessing muscle mass and muscle quality in chronic kidney disease.Clinical kidney journal · 2024Review
- Concordance between muscle mass assessed by bioelectrical impedance analysis and by muscle ultrasound: a cross-sectional study in a cohort of patients on chronic hemodialysis.BMC nephrology · 2024Article
- [Intensive care unit-acquired weakness-Diagnostic value of neuromuscular ultrasound].Die Anaesthesiologie · 2023Review
- Novel Tools to Assess Muscle Sarcopenic Process in ICU Patients: Are They Worthwhile?Journal of clinical medicine · 2023Article
- Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions.Medicina (Kaunas, Lithuania) · 2023Review
- Quadriceps muscle thickness assessed by ultrasound is independently associated with mortality in hemodialysis patients.European journal of clinical nutrition · 2022Article
- Ultrasonic Image Features under the Intelligent Algorithm in the Diagnosis of Severe Sepsis Complicated with Renal Injury.Computational and mathematical methods in medicine · 2022Article
- Feasibility of computed tomography-based assessment of skeletal muscle mass in hemodialysis patients.Journal of nephrology · 2021Article
- Ultrasound for Non-invasive Assessment and Monitoring of Quadriceps Muscle Thickness in Critically Ill Patients With Acute Kidney Injury.Frontiers in nutrition · 2021Article
- Estimation of Muscle Mass in the Integrated Assessment of Patients on Hemodialysis.Frontiers in nutrition · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccelerated muscle wasting still represents a major issue in critically ill patients. However, a key problem in the intensive care unit is the lack of adequate tools for bedside evaluation of muscle mass. Moreover, when acute kidney injury (AKI) coexists, fluid overload and/or rapid fluid shifts due to renal replacement therapies that frequently occur and may interfere with muscle mass assessment. The purpose of this study is to validate muscle ultrasound (US) by a gold standard (muscle CT scan) for the assessment of quadriceps muscle thickness in critically ill patients with AKI.
methodsQuadriceps rectus femoris thickness and quadriceps vastus intermedius thickness of critically ill patients with AKI were blindly assessed at the same leg sites by both US and computed tomography (CT) scan. Using bivariate mixed-model linear regression analysis, we estimated, average difference in thickness between measurement sites, agreement (differential and proportional bias) of US compared to CT, and precision of the two methods, and eventually performed Bland-Altman analysis for repeated measurements on pooled results.
resultsWe analyzed 233 couples of measurements (30 patients). Average muscle thickness ranged between 1.0 and 1.6, depending on the measurement site. When comparing US to CT, both the observed differential bias (between + 0.04 and + 0.26 cm depending on the muscle site) and the proportional bias (between 82 and 98% of the reference values, depending on the muscle site) were not statistically significant. However, precision analysis showed that US scan tended to be slightly less precise in comparison to CT. Bland-Altman analysis on pooled results showed that the 95% limits of agreement between the US and CT were narrow, ranging from - 0.34 to + 0.36 cm.
conclusionIn critically ill patients with AKI, quadriceps muscle thickness assessment based on US is unbiased, although it occurs with a minor loss of precision compared to CT.
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