Evidence map›Paper›PMID 31729632›Full record

ArticleMolecular neurobiology2020

P2X7 Purinergic Receptor Is Involved in the Pathophysiology of Mania: a Preclinical Study.

Carolina Gubert, Roberta Andrejew, Carlos Eduardo Leite, Cesar Eduardo Jacintho Moritz, Juliete Scholl, Fabricio Figueiro, Flávio Kapczinski, Pedro Vieira da Silva Magalhães, Ana Maria Oliveira Battastini

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  8. The P2X7 Receptor: Central Hub of Brain Diseases.Frontiers in molecular neuroscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Carolina GubertPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, Porto Alegre, RS, 90035-003, Brazil. gubert.cm@gmail.com.ORCID http://orcid.org/0000-0002-8078-1390
Roberta AndrejewPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, Porto Alegre, RS, 90035-003, Brazil.
Carlos Eduardo LeiteInstituto de Toxicologia e Farmacologia, Pontifícia Universidade Católica do Rio Grande do Sul, Avenida Ipiranga, 6681, Porto Alegre, RS, 90619-900, Brazil.
Cesar Eduardo Jacintho MoritzPrograma de Pós-Graduação em Ciências do Movimento Humano, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Juliete SchollPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, Porto Alegre, RS, 90035-003, Brazil.
Fabricio FigueiroPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, Porto Alegre, RS, 90035-003, Brazil.
Flávio KapczinskiDepartment of Psychiatry and Behavioral Sciences, MacMaster University, Hamilton, Canada.
Pedro Vieira da Silva MagalhãesHospital de Clínicas de Porto Alegre, Porto Alegre, RS, 90035-003, Brazil.
Ana Maria Oliveira BattastiniPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, Porto Alegre, RS, 90035-003, Brazil.
Universidade Federal do Rio Grande do Sul · BRMcMaster University · CAPontifícia Universidade Católica do Rio Grande do Sul · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 303264/2013-6
6 · The paper itself

Abstract

The pathophysiology of bipolar disorder remains incompletely elucidated. The purinergic receptor, P2X7 (P2X7R), plays a central role in neuroinflammation, the establishment, and maintenance of microglial activation and neuronal damage/death, all characteristics of bipolar disorder pathology. The present study aims to explore the participation of the P2X7R in a preclinical pharmacological model of mania. We analyzed the modulatory effects of the P2X7R antagonist, brilliant blue, on behavior, monoamines, gene expression, serum purine levels, and cell typing in a pharmacological model of mania induced by D-amphetamine (AMPH) in mice. Our results corroborate an association between the P2X7 receptor and the preclinical animal model of mania, as demonstrated by the decreased responsiveness to AMPH in animals with pharmacologically blocked P2X7R. This study further suggests a possible dopaminergic mechanism for the action of P2X7 receptor antagonism. Additionally, we observed increased peripheral levels of adenosine, a neuroprotective molecule, and increased central expression of Entpd3 and Entpd1 leading to the hydrolysis of ATP, a danger signal, possibly as an attempt to compensate for the damage induced by AMPH. Lastly, P2X7R antagonism in the AMPH model was found to potentially modulate astrogliosis. Our results support the hypothesis that P2X7R plays a vital role in the pathophysiology of mania, possibly by modulating the dopaminergic pathway and astrogliosis, as reflected in the behavioral changes observed. Taken together, this study suggests that a purinergic system imbalance is associated with the AMPH-induced preclinical animal model of mania. P2X7R may represent a promising molecular therapeutic target for bipolar disorder.

Indexed as

Adenosine TriphosphateAnimalsBipolar DisorderCell DeathDisease Models, AnimalGliosisHippocampusMaleMice, Inbred C57BLPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7Adenosine TriphosphatePurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7AdenosineAmphetamineAstrogliosisBipolar disorderCD39Dopaminergic axisENTPD1ENTPD3P2X7R

Identifiers

PMID31729632
OpenAlexW2984465301

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.