Evidence map›Paper›PMID 31729609›Full record

ArticleLasers in medical science2020

Physical exercise and low-level laser therapy on the nociception and leukocyte migration of Wistar rats submitted to a model of rheumatoid arthritis.

Morgana Neves, Ana Caroline Barbosa Retameiro, Alana Ludemila de Freitas Tavares, Aline Reginato, Rafael Andrade Menolli, Taciane Stein da Silva Leal, Lucinéia de Fátima Chasko Ribeiro, Gladson Ricardo Flor Bertolini

Abstract read
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Morgana NevesUniversidade Estadual do Oeste do Paraná (Unioeste), Universitaria St. 2069, Cascavel, Paraná, 85819-110, Brazil.
Ana Caroline Barbosa RetameiroUniversidade Estadual do Oeste do Paraná (Unioeste), Universitaria St. 2069, Cascavel, Paraná, 85819-110, Brazil.
Alana Ludemila de Freitas TavaresUniversidade Estadual do Oeste do Paraná (Unioeste), Universitaria St. 2069, Cascavel, Paraná, 85819-110, Brazil.
Aline ReginatoUniversidade Estadual do Oeste do Paraná (Unioeste), Universitaria St. 2069, Cascavel, Paraná, 85819-110, Brazil.
Rafael Andrade MenolliUniversidade Estadual do Oeste do Paraná (Unioeste), Universitaria St. 2069, Cascavel, Paraná, 85819-110, Brazil.
Taciane Stein da Silva LealUniversidade Estadual do Oeste do Paraná (Unioeste), Universitaria St. 2069, Cascavel, Paraná, 85819-110, Brazil.
Lucinéia de Fátima Chasko RibeiroUniversidade Estadual do Oeste do Paraná (Unioeste), Universitaria St. 2069, Cascavel, Paraná, 85819-110, Brazil.
Gladson Ricardo Flor BertoliniUniversidade Estadual do Oeste do Paraná (Unioeste), Universitaria St. 2069, Cascavel, Paraná, 85819-110, Brazil. Gladson_ricardo@yahoo.com.br.ORCID http://orcid.org/0000-0003-0565-2019
Universidade Estadual do Oeste do Paraná · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Acknowledgement to the CAPES for the PNPD scholarship.
6 · The paper itself

Abstract

Rheumatoid arthritis denotes hyperplasia and intense inflammatory process. Treatment involves exercise protocols and use of resources such as low-level laser therapy (LLLT) to modulate the inflammatory process and maintain physical capacity. The objective was to investigate whether treatment with LLLT and exercise modulates the inflammatory process and peripheral functionality. Sample is composed of 128 male rats, separated into three groups, control, treated and untreated, in the acute and chronic period of the disease with 64 animals in each group, divided into 8 subgroups with n = 8. The animals were immunized with injection at the base of the tail and 7 days after intra-articular injection with complete Freund adjuvant (CFA) for lesion groups, and saline solution for the controls. Joint disability was evaluated by PET (paw elevation time) and joint edema and treated with LLLT and/or resisted stair climbing exercise. Normality Shapiro-Wilk test, ANOVA mixed for the functional analyses, and ANOVA one-way for the variables of cellular differentiation, with Bonferroni post hoc, p = 5% were used. For the evaluations of joint disability and nociception, there was a significant difference between the evaluations, the groups, and the interaction groups-evaluations. The treated groups showed recovery of functionality; it is still verified that laser therapy increased the nociceptive threshold of the chronic inflammatory period, and the exercise reflected in significant functional improvement and modulation of the inflammatory process both in the acute and chronic periods. LLLT, resistance exercise, or a combination of treatments had a positive effect on the modulation of the inflammatory process, reducing the migration of leukocytes, in addition to helping the return of peripheral functionality by reducing joint disability in a model of rheumatoid arthritis induced by CFA in rats.

Indexed as

Cell MovementLow-Level Light TherapyPhysical Conditioning, AnimalAnimalsArthritis, RheumatoidEdemaInflammationLeukocytesMaleNociceptionPositron-Emission TomographyRats, WistarSynovial FluidExerciseLaser therapyLeukocyte countNeurogenic inflammationRheumatoid arthritis

Identifiers

PMID31729609
OpenAlexW2986298879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.