Evidence map›Paper›PMID 31729565›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020

Health-related quality of life and oncologic outcomes after surgery in older adults with colorectal cancer.

Andrew M Blakely, Dayana Chanson, F Lennie Wong, Oliver S Eng, Stephen M Sentovich, Kurt A Melstrom, Lily L Lai, Yuman Fong, Virginia Sun

Abstract read
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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Health-related quality of life trajectories in older adult long-term survivors of colorectal cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrew M BlakelyDepartment of Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91104, USA. andrew.blakely@nih.gov.ORCID http://orcid.org/0000-0002-5013-3851
Dayana ChansonDepartment of Graduate Medical Education and Clinical Training, City of Hope National Medical Center, Duarte, CA, USA.
F Lennie WongDepartment of Population Sciences, City of Hope National Medical Center, Duarte, CA, USA.
Oliver S EngSection of General Surgery and Surgical Oncology, University of Chicago, Chicago, IL, USA.
Stephen M SentovichDepartment of Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91104, USA.
Kurt A MelstromDepartment of Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91104, USA.
Lily L LaiDepartment of Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91104, USA.
Yuman FongDepartment of Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91104, USA.
Virginia SunDepartment of Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91104, USA.

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
NCI NIH HHS P30 CA033572
6 · The paper itself

Abstract

purposeData regarding changes in functional status and health-related quality of life (HRQOL) before and after surgery are lacking. We identified colorectal cancer patients from the SEER-Medicare Health Outcomes Survey (MHOS) linked database to evaluate the association between HRQOL and survival.

methodsHRQOL survey data captured physical/mental health, activities of daily living (ADLs), and medical comorbidities. Patients who underwent surgery with HRQOL surveys prior to cancer diagnosis and ≥ 1 year after diagnosis were selected. Patient, disease, and HRQOL measures were analyzed in regard to overall survival (OS), disease-specific survival (DSS), and non-DSS.

resultsOf 590 patients included, 55% were female, 75% were Caucasian, and 83% had colonic primary. Disease extent was localized for 52%, regional for 41%, and distant for 7%. Median OS was 83 months. Decreased OS was independently associated with age ≥ 75 (HR 1.7, p < 0.0001), male sex (HR 1.4, p = 0.011), advanced disease (regional-HR 2.0, p < 0.0001; distant-HR 7.0, p < 0.0001), and decreased mental HRQOL (HR 1.4, p = 0.005). Decreased DSS was independently associated with advanced disease (regional-HR 4.1, p < 0.0001; distant-HR 16.5, p < 0.0001) and rectal primary (HR 1.6, p = 0.047). Decreased non-DSS was independently associated with age ≥ 75 (HR 2.2, p < 0.0001), male sex (HR 1.4, p = 0.03), decreased mental HRQOL (HR 1.4, p = 0.02), and increased comorbidities (HR 1.4, p = 0.04).

conclusionsThe potential overall survival benefit of oncologic surgery is diminished by declines in physical and mental health. Early identification of older surgical patients at risk for functional and HRQOL declines may improve survival following colorectal cancer surgery.

Indexed as

AgedAged, 80 and overColorectal NeoplasmsFemaleHumansMaleMiddle AgedQuality of LifeSurvival AnalysisTreatment OutcomeColorectal cancerFunctional statusGeriatric oncologyQuality of life

Identifiers

PMID31729565
PMCPMC7700837

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.