Evidence map›Paper›PMID 31729429›Full record

ArticleScientific reports2019

High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na

Paul A Wadsworth, Oluwarotimi Folorunso, Nghi Nguyen, Aditya K Singh, Daniela D'Amico, Reid T Powell, David Brunell, John Allen, Clifford Stephan, Fernanda Laezza

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Differential Modulation of the Voltage-Gated NaFrontiers in molecular biosciences · 2021
    Article
  10. Article
  11. JAK2 regulates Nav1.6 channel function via FGF14Biochimica et biophysica acta. Molecular cell research · 2020
    Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Paul A WadsworthMD/PhD Combined Degree Program and Biochemistry and Molecular Biology Graduate Program, The University of Texas Medical Branch, Galveston, Texas, 77555, USA.ORCID http://orcid.org/0000-0002-4562-7830
Oluwarotimi FolorunsoDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, Texas, 77555, USA.
Nghi NguyenHTS Screening Core, Center for Translational Cancer Research, Texas A&M Health Science Center: Institute of Biosciences and Technology, Houston, TX, 77030, USA.
Aditya K SinghDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, Texas, 77555, USA.
Daniela D'AmicoNeuroscience Graduate Program, The University of Texas Medical Branch, Galveston, Texas, 77555, USA.
Reid T PowellHTS Screening Core, Center for Translational Cancer Research, Texas A&M Health Science Center: Institute of Biosciences and Technology, Houston, TX, 77030, USA.
David BrunellHTS Screening Core, Center for Translational Cancer Research, Texas A&M Health Science Center: Institute of Biosciences and Technology, Houston, TX, 77030, USA.
John AllenDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, Texas, 77555, USA.
Clifford StephanHTS Screening Core, Center for Translational Cancer Research, Texas A&M Health Science Center: Institute of Biosciences and Technology, Houston, TX, 77030, USA.
Fernanda LaezzaDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, Texas, 77555, USA. felaezza@utmb.edu.
The University of Texas Medical Branch at Galveston · USTexas A&M Health Science Center · US

Funding

Validation of FGF14 as a New Molecular Target of GSK3R01MH095995 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2012 to 2016
$1.9M
Discovery of Chemical Probes for Psychiatric Disorders and AddictionR01MH111107 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA, ZHOU, JIA · 2016 to 2018
$1.6M
Clinical and Behavioral Science Training in Aging and Health DisparitiesT32AG051131 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MARKIDES, KYRIAKOS S · 2015 to 2019
$436k
Malvern MicroCal PEAQ Isothermal Titration CalorimeterS10OD023576 · OD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RAJARATHNAM, KRISHNA · 2017 to 2017
$120k
NIA NIH HHS T32 AG051131NIH HHS S10 OD023576NIMH NIH HHS R01 MH095995NIMH NIH HHS R01 MH111107
6 · The paper itself

Abstract

Multiple voltage-gated Na

Indexed as

Antineoplastic AgentsDrug Evaluation, PreclinicalFibroblast Growth FactorsHEK293 CellsHigh-Throughput Screening AssaysHumansMultiprotein ComplexesNAV1.6 Voltage-Gated Sodium ChannelProtein BindingProtein Interaction MapsVoltage-Gated Sodium Channel AgonistsVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium ChannelsAntineoplastic Agentsfibroblast growth factor 14Fibroblast Growth FactorsMultiprotein ComplexesNAV1.6 Voltage-Gated Sodium ChannelVoltage-Gated Sodium Channel AgonistsVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium Channels

Identifiers

PMID31729429
PMCPMC6858373
OpenAlexW2987762368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.