ArticleNature communications2019
Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 238 citations in OpenAlex.
- Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics.Frontiers in bioengineering and biotechnology · 2021Pooled it
- Seamless human electronics interfacing through advanced skin attachable and implantable sensor technologies.Discover nano · 2026Review
- Time-staggered chemo-immunotherapy via engineered nanofiber resists postoperative dynamic immunosuppression in glioblastoma.Nature communications · 2026Article
- Flexible biodegradable wireless battery-free integrated theranostic adhesive patch.Bioactive materials · 2026Article
- Tissue-bioelectronics interfaces.Chemical Society reviews · 2026Review
- Polymer-Based Flexible Wireless Sensors for Health Monitoring.Nano-micro letters · 2026Review
- Thermally Degradable Biocompatible Hydrogel as Transient Encapsulation Coating for Implantable Sensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multiparametric Bioresorbable Sensor for Doxorubicin Detection via Molecularly Imprinted Synthetic Receptors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Brain-Adhesive Bioelectronics With Shape-Morphable and Biodegradable Properties for Stable Brain Signal Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neuron-targeted 2-deoxyglucose-dendrimer-rosiglitazone nanotherapy mitigates neuroinflammation and cognitive deficits in pediatric traumatic brain injury.Bioengineering & translational medicine · 2026Article
- Review
- Advancements in Drug Delivery Systems in Glioblastoma Therapy.International journal of molecular sciences · 2026Review
- Breaking Barriers: Advancements in CNS Drug Delivery for Glioblastoma.Medical sciences (Basel, Switzerland) · 2026Review
- Engineering Glioma-Cell-Derived Exosomes as Trojan Horse for Precisely Targeted Chemotherapy of Glioblastoma.Biomaterials research · 2026Article
- Soft bioelectronics for wireless drug delivery: programmable, minimally invasive and closed-loop therapeutics.npj soft matter · 2026Review
- Article
- Hydrogel-elastomer-based conductive nanomembranes for soft bioelectronics.Nature nanotechnology · 2025Article
- Biomimetic Porous Coatings on a Biocompatible Ti-15Mo Alloy as a Platform for Local Delivery of Anticancer Drugs to Patient Tissues.Biomedicines · 2025Article
- NFC/RFID-enabled wearables and implants for biomedical applications.Microsystems & nanoengineering · 2025Review
- Solution-processable and photo-curable system for low-cost and scalable transient electronics.Nature communications · 2025Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 4 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intracranial drug delivery through mild-thermic actuation. The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid. Biodegradation of the entire device minimizes potential neurological side-effects. Application of the device to the mouse model confirms tumor volume suppression and improved survival rate. Demonstration in a large animal model (canine model) exhibited its potential for human application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.