Evidence map›Paper›PMID 31729371›Full record

ArticleNature communications2019

Toll-like receptor 2 expression on c-kit

Jana Balounová, Iva Šplíchalová, Martina Dobešová, Michal Kolář, Karel Fišer, Jan Procházka, Radislav Sedlacek, Andrea Jurisicova, Hoon-Ki Sung, Vladimír Kořínek and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Maternal NOProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Mds1Cell reports · 2021
    Article
  9. Tissue-Resident Macrophage Development and Function.Frontiers in cell and developmental biology · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jana BalounováLaboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Iva ŠplíchalováLaboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Martina DobešováLaboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Michal KolářLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Karel FišerChildhood Leukaemia Investigation Prague, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-7265-3268
Jan ProcházkaCzech Centre for Phenogenomics & Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Radislav SedlacekCzech Centre for Phenogenomics & Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Andrea JurisicovaSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Hoon-Ki SungThe Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Vladimír KořínekLaboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Meritxell Alberich-JordaLaboratory of Hematooncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Isabelle GodinInstitute Gustave Roussy PR1, INSERM U1170, Villejuif, France.ORCID http://orcid.org/0000-0001-8577-8388
Dominik FilippLaboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. dominik.filipp@img.cas.cz.ORCID http://orcid.org/0000-0003-2506-9330

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoiesis in mammalian embryos proceeds through three successive waves of hematopoietic progenitors. Since their emergence spatially and temporally overlap and phenotypic markers are often shared, the specifics regarding their origin, development, lineage restriction and mutual relationships have not been fully determined. The identification of wave-specific markers would aid to resolve these uncertainties. Here, we show that toll-like receptors (TLRs) are expressed during early mouse embryogenesis. We provide phenotypic and functional evidence that the expression of TLR2 on E7.5 c-kit

Indexed as

Adult Stem CellsAnimalsFemaleHematopoiesisHematopoietic Stem CellsMaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-kitToll-Like Receptor 2Proto-Oncogene Proteins c-kitToll-Like Receptor 2

Identifiers

PMID31729371
PMCPMC6858454

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.