ArticleJournal of veterinary internal medicine2020
Plasma renin activity and aldosterone concentration in dogs with acquired portosystemic collaterals.
Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Urinary sodium indices do not reliably differentiate stage B2 myxomatous mitral valve disease in dogs from healthy dogs.Frontiers in veterinary science · 2026Article
- Age- and sex-specific reference intervals for renin and aldosterone in healthy individuals in Yunnan Province, China.Journal of human hypertension · 2025Article
- Prognostic indicators in dogs with intra-hepatic portal hypertension.The Canadian veterinary journal = La revue veterinaire canadienne · 2023Article
- Serum 25-hydroxyvitamin D and C-reactive protein and plasma von Willebrand concentrations in 23 dogs with chronic hepatopathies.Journal of veterinary internal medicine · 2022Article
- Changes in renin-angiotensin-aldosterone system during cardiac remodeling after mitral valvuloplasty in dogs.Journal of veterinary internal medicine · 2022Article
- Plasma renin activity and aldosterone concentration in dogs with acquired portosystemic collaterals.Journal of veterinary internal medicine · 2020Article
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Authors and funding
4 authors.
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Abstract
backgroundThe renin-angiotensin-aldosterone system (RAAS) is activated in humans with portal hypertension (PH) associated with liver disease. However, involvement of RAAS in dogs with intrahepatic PH is not clear.
objectiveTo measure plasma renin activity (PRA) and plasma aldosterone concentration (PAC) in dogs with PH (chronic hepatitis [CH] and primary hypoplasia of the portal vein [PHPV]), dogs with extrahepatic congenital portosystemic shunt (EH-CPSS), and healthy dogs and to determine whether the RAAS is activated in dogs with PH. ANIMALS: Twenty-seven dogs with acquired portosystemic collaterals (APSCs; 15 dogs with CH, 12 dogs with PHPV), 9 dogs with EH-CPSS, and 10 healthy dogs.
methodsRetrospective study. Plasma renin activity and PAC were measured by radioimmunoassay.
resultsPlasma renin activity was significantly higher in the CH group (median, 4.4 ng/mL/h) than in the EH-CPSS (median, 1.0 ng/mL/h; P < .01) and the healthy (median, 1.1 ng/mL/h; P < .01) groups. No significant differences were found between the PHPV group (median, 2.2 ng/mL/h) and other groups. Plasma aldosterone concentration was significantly higher in the CH (median, 111.0 pg/mL) and PHPV (median, 89.5 pg/mL) groups than in the EH-CPSS (median, 1.0 pg/mL; P < .001, P < .01, respectively) and healthy (median, 14.5 pg/mL; P < .001, P < .05, respectively) groups. CONCLUSIONS AND CLINICAL IMPORTANCE: Activation of the RAAS contributes to the pathophysiology of intrahepatic PH in dogs, suggesting that spironolactone may not only be effective for the treatment of ascites but also for the suppression of intrahepatic PH.
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