Evidence map›Paper›PMID 31729089›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

Simultaneous Production of Psilocybin and a Cocktail of β-Carboline Monoamine Oxidase Inhibitors in "Magic" Mushrooms.

Felix Blei, Sebastian Dörner, Janis Fricke, Florian Baldeweg, Felix Trottmann, Anna Komor, Florian Meyer, Christian Hertweck, Dirk Hoffmeister

Open access · hybridAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Clade III Synthases Add Cyclic and Linear Terpenoids to the Psilocybe Metabolome.Chembiochem : a European journal of chemical biology · 2025
    Article
  10. Chemical Composition and Biological Activities ofPharmaceuticals (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Engineering in life sciences · 2025
    Review
  13. Article
  14. Review
  15. Cultivation, chemistry, and genome ofJournal of psychedelic studies · 2024
    Article
  16. Review
  17. A bacterial-like Pictet-Spenglerase drives the evolution of fungi to produce β-carboline glycosides together with separate genes.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Article
  19. Review
  20. DNA Authentication and Chemical Analysis ofApplied and environmental microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Felix BleiDepartment Pharmaceutical Microbiology, Hans Knöll Institute, Friedrich Schiller University, Beutenbergstrasse 11a, 07745, Jena, Germany.
Sebastian DörnerDepartment Pharmaceutical Microbiology, Hans Knöll Institute, Friedrich Schiller University, Beutenbergstrasse 11a, 07745, Jena, Germany.
Janis FrickeDepartment Pharmaceutical Microbiology, Hans Knöll Institute, Friedrich Schiller University, Beutenbergstrasse 11a, 07745, Jena, Germany.
Florian BaldewegDepartment Pharmaceutical Microbiology, Hans Knöll Institute, Friedrich Schiller University, Beutenbergstrasse 11a, 07745, Jena, Germany.
Felix TrottmannDepartment Biomolecular Chemistry, Leibniz Institute for Natural, Product Research and Infection Biology-Hans Knöll Institute, Beutenbergstrasse 11a, 07745, Jena, Germany.
Anna KomorDepartment Biomolecular Chemistry, Leibniz Institute for Natural, Product Research and Infection Biology-Hans Knöll Institute, Beutenbergstrasse 11a, 07745, Jena, Germany.
Florian MeyerTransfer Group Anti-Infectives, Leibniz Institute for Natural Product, Research and Infection Biology-Hans Knöll Institute, Beutenbergstrasse 11a, 07745, Jena, Germany.
Christian HertweckDepartment Biomolecular Chemistry, Leibniz Institute for Natural, Product Research and Infection Biology-Hans Knöll Institute, Beutenbergstrasse 11a, 07745, Jena, Germany.
Dirk HoffmeisterDepartment Pharmaceutical Microbiology, Hans Knöll Institute, Friedrich Schiller University, Beutenbergstrasse 11a, 07745, Jena, Germany.ORCID http://orcid.org/0000-0002-5302-6461
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DE

Funding

Deutsche Forschungsgemeinschaft HO2515/7-1Deutsche Forschungsgemeinschaft SFB1127
6 · The paper itself

Abstract

The psychotropic effects of Psilocybe "magic" mushrooms are caused by the l-tryptophan-derived alkaloid psilocybin. Despite their significance, the secondary metabolome of these fungi is poorly understood in general. Our analysis of four Psilocybe species identified harmane, harmine, and a range of other l-tryptophan-derived β-carbolines as their natural products, which was confirmed by 1D and 2D NMR spectroscopy. Stable-isotope labeling with

Indexed as

AgaricalesAlkaloidsCarbolinesMonoamine OxidaseMonoamine Oxidase InhibitorsPsilocybinTryptophanAlkaloidsCarbolinesMonoamine OxidaseMonoamine Oxidase InhibitorsnorharmanPsilocybinTryptophanalkaloidsayahuascabeta-carbolinenatural productspsilocybin

Identifiers

PMID31729089
PMCPMC7003923
OpenAlexW2983552824

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.