Evidence map›Paper›PMID 31729076›Full record

ReviewEuropean journal of haematology2020

The many roles of tranexamic acid: An overview of the clinical indications for TXA in medical and surgical patients.

Johnny Cai, Jessica Ribkoff, Sven Olson, Vikram Raghunathan, Hanny Al-Samkari, Thomas G DeLoughery, Joseph J Shatzel

4 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of haematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 120 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 15 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04846114 nacompletednot on this map

Efficacy of Local Hemostatic Management in Implant Surgery in Anticoagulated Patients on Warfarin: a Randomized Clinical Study

TypeinterventionalSponsorJorge Ernesto AguilarRan2016 to 2019Enrolled71ConditionsOral Anticoagulant TherapyArmsDental implant surgery
NCT05345613 phase4recruitingnot on this mapstarted 2022, after this paper: background citation

Usage of Tranexamic Acid During Colonic Endoscopic Resection Procedures for Reduction Intraprocedural and Postprocedural Bleeding

TypeinterventionalSponsorAssaf-Harofeh Medical CenterRan2022 to 2026Enrolled200ConditionsColon NeoplasmArmsTranexamic acid, Standard
NCT05713630 phase3recruitingnot on this mapstarted 2026, after this paper: background citation

TRACE STUDY: A Randomized Controlled Trial Using Tranexamic Acid in the Treatment of Subdural Hematoma

TypeinterventionalSponsorUnity Health TorontoRan2026 to 2030Enrolled130ConditionsSubdural HematomaArmsTranexamic acid (TXA), Placebo
NCT06266546 phase3active not recruitingnot on this mapstarted 2024, after this paper: background citation

Prophylactic Endobronchial Tranexamic Acid to Reduce Bleeding in Transbronchial Cryobiopsy

TypeinterventionalSponsorYoussef YammineRan2024 to 2028Enrolled100ConditionsHemorrhage Lung, Endobronchial MassArmsTranexamic acid
3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 15 syntheses or guidelines pooled it, 237 citations in OpenAlex.

  1. Comparative efficacy and safety of different tranexamic acid administration in spine surgery: a network meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  6. Efficacy and safety of Tranexamic acid use on postoperative blood transfusion in hip fracture patients- a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Pooled it
  7. Nebulized tranexamic acid for treatment of post-tonsillectomy bleeding: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
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  15. Meta-Analysis of the Efficacy and Safety of Tranexamic Acid in Spinal Surgery.Computational and mathematical methods in medicine · 2022
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  18. A comparative study on hemostasis effect of different application methods and time of tranexamic acid in total hip arthroplasty.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
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  19. [Efficacy and safety of multiple-dose intravenous tranexamic acid for reducing blood loss in complex tibial plateau fractures: A prospective randomized controlled trial].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023
    Trial
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Johnny CaiDepartment of Internal Medicine, Oregon Health and Science University, Portland, Oregon.
Jessica RibkoffSchool of Medicine, Oregon Health and Science University, Portland, Oregon.ORCID https://orcid.org/0000-0002-2209-9000
Sven OlsonDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.
Vikram RaghunathanDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.
Hanny Al-SamkariDivision of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Thomas G DeLougheryDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.ORCID https://orcid.org/0000-0002-5790-4700
Joseph J ShatzelDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.ORCID https://orcid.org/0000-0001-9396-5976
Oregon Health & Science University · USHarvard University · US

Funding

Characterization of Coagulation Factor-platelet Interactions: Role of FXIR01HL101972 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Owen J McCarty · 2010 to 2026
$8.5M
NHLBI NIH HHS R01 HL101972
6 · The paper itself

Abstract

Clinically significant bleeding can occur as a consequence of surgery, trauma, obstetric complications, anticoagulation, and a wide variety of disorders of hemostasis. As the causes of bleeding are diverse and not always immediately apparent, the availability of a safe, effective, and non-specific hemostatic agent is vital in a wide range of clinical settings, with antifibrinolytic agents often utilized for this purpose. Tranexamic acid (TXA) is one of the most commonly used and widely researched antifibrinolytic agents; its role in postpartum hemorrhage, menorrhagia, trauma-associated hemorrhage, and surgical bleeding has been well defined. However, the utility of TXA goes beyond these common indications, with accumulating data suggesting its ability to reduce bleeding and improve clinical outcomes in the face of many different hemostatic challenges, without a clear increase in thrombotic risk. Herein, we review the literature and provide practical suggestions for clinical use of TXA across a broad spectrum of bleeding disorders.

Indexed as

Antifibrinolytic AgentsBlood Loss, SurgicalFemaleHumansMaleMenorrhagiaPostpartum HemorrhageTranexamic AcidWounds and InjuriesAntifibrinolytic AgentsTranexamic Acidantifibrinolytic agentscoagulantsfibrin modulating agentsheavy menstrual bleedinghematologic agentshematologic disordershemophiliahemorrhagehemostaticpostpartum hemorrhagetranexamic acidtrauma

Identifiers

PMID31729076
PMCPMC7023891
OpenAlexW2987123986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.