Evidence map›Paper›PMID 31728930›Full record

ArticleMolecular neurobiology2020

TREK-1 Null Impairs Neuronal Excitability, Synaptic Plasticity, and Cognitive Function.

Wei Wang, Conrad M Kiyoshi, Yixing Du, Anne T Taylor, Erica R Sheehan, Xiao Wu, Min Zhou

Open access · greenAbstract read
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. TREK-1 and epilepsy: regulating the balance of KBehavioral and brain functions : BBF · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
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  18. Review
  19. Approaches to Study Gap Junctional Coupling.Frontiers in cellular neuroscience · 2021
    Review
  20. Astrocytes in Addictive Disorders.Advances in neurobiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Wei WangDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Conrad M KiyoshiDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Yixing DuDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Anne T TaylorDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Erica R SheehanDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Xiao WuDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Min ZhouDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA. zhou.787@osu.edu.ORCID http://orcid.org/0000-0001-6249-2977
The Ohio State University Wexner Medical Center · US

Funding

Ohio State University Neuroscience Center Core-Core EP30NS104177 · NINDS · OHIO STATE UNIVERSITY · PI BROWN, ANTHONY · 2017 to 2020
$1.9M
Functional plasticity of astrocyte syncytial networkR01NS116059 · NINDS · OHIO STATE UNIVERSITY · PI ZHOU, MIN · 2020 to 2024
$1.9M
Involvement of astrocytic two-pore domain K+ channels in ischemic pathologyR01NS062784 · NINDS · ORDWAY RESEARCH INSTITUTE, INC. · PI ZHOU, MIN · 2010 to 2014
$1.7M
Astrocyte function at syncytial system levelsR56NS097672 · NINDS · OHIO STATE UNIVERSITY · PI ZHOU, MIN · 2016 to 2016
$385k
NINDS NIH HHS P30 NS104177NINDS NIH HHS R01 NS062784NINDS NIH HHS R01 NS116059NINDS NIH HHS R56 NS097672NINDS NIH HHS R56NS097972NINDS NIH HHS RO1NS062784
6 · The paper itself

Abstract

TREK-1, a two-pore-domain K

Indexed as

AnimalsAstrocytesCognitionExcitatory Postsynaptic PotentialsHippocampusLong-Term PotentiationMice, KnockoutNeuronal PlasticityNeuronsPotassium Channels, Tandem Pore DomainPyramidal CellsSynapsesSynaptic Transmissionpotassium channel protein TREK-1Potassium Channels, Tandem Pore DomainCognitive impairmentHippocampusSynaptic plasticitySynaptic transmissionTREK-1 (tandem of pore domain in a weak inwardly rectifying K+ channel (Twik)-related K+ channels)

Identifiers

PMID31728930
PMCPMC8808335
OpenAlexW2983503245

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.