Evidence map›Paper›PMID 31728918›Full record

ArticleClinical journal of gastroenterology2020

Could JC virus be linked to chronic idiopathic intestinal pseudo-obstruction?

Emanuele Sinagra, Dario Raimondo, Elena Gallo, Marco Calvaruso, Vincenzo Luca Lentini, Alessandra Cannizzaro, Cristina Linea, Marco Giunta, Luigi Maria Montalbano, Gennaro D'Amico and 1 more

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Clinical journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Emanuele SinagraEndoscopy Unit, Contrada Pietra Pollastra Pisciotto, Fondazione Istituto San Raffaele-G. Giglio, 90015, Cefalù, Italy.
Dario RaimondoEndoscopy Unit, Contrada Pietra Pollastra Pisciotto, Fondazione Istituto San Raffaele-G. Giglio, 90015, Cefalù, Italy.
Elena GalloUnit of Pathology, Ospedali Riuniti "Villa Sofia-Cervello, University of Palermo, via trabucco 180, 90136, Palermo, Italy.
Marco CalvarusoContrada Pietra Pollastra Pisciotto, Istituto Di Bioimmagini E Fisiologia Molecolare, IBFM-CNR, 90015, Cefalù, Italy.
Vincenzo Luca LentiniUnit of Pathology, Ospedali Riuniti "Villa Sofia-Cervello, University of Palermo, via trabucco 180, 90136, Palermo, Italy. vincenzolucalentini@gmail.com.ORCID http://orcid.org/0000-0002-3679-3968
Alessandra CannizzaroUnit of Pathology, Ospedali Riuniti "Villa Sofia-Cervello, University of Palermo, via trabucco 180, 90136, Palermo, Italy.
Cristina LineaUnit of Gastroenterology, Ospedali Riuniti "Villa Sofia-Cervello, University of Palermo, via trabucco 180, 90136, Palermo, Italy.
Marco GiuntaUnit of Gastroenterology, Ospedali Riuniti "Villa Sofia-Cervello, University of Palermo, via trabucco 180, 90136, Palermo, Italy.
Luigi Maria MontalbanoUnit of Gastroenterology, Ospedali Riuniti "Villa Sofia-Cervello, University of Palermo, via trabucco 180, 90136, Palermo, Italy.
Gennaro D'AmicoUnit of Gastroenterology, Ospedali Riuniti "Villa Sofia-Cervello, University of Palermo, via trabucco 180, 90136, Palermo, Italy.
Aroldo Gabriele RizzoUnit of Pathology, Ospedali Riuniti "Villa Sofia-Cervello, University of Palermo, via trabucco 180, 90136, Palermo, Italy.
Ospedale Vincenzo Cervello · ITFondazione Istituto G. Giglio di Cefalù · ITInstitute of Molecular Bioimaging and Physiology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

JC virus is a member of the Polyomavirus family, infects humans worldwide, and 90% of the population carry antibodies to the virus by adult life. The initial infection is asymptomatic, but it may become persistent. JC virus DNA is frequently present in the upper and lower gastrointestinal tracts of healthy adults. Chronic idiopathic intestinal pseudo-obstruction, one of the most severe gastrointestinal motility disorders, is a condition characterized by a clinical picture mimicking small bowel occlusion with related symptoms and signs in the absence of demonstrable mechanical obstruction. Because of the known neuropathic capability of this virus, and its frequent presence in the gut, it has been proposed that JCV might be detectable in tissues of patients with chronic idiopathic intestinal pseudo-obstruction, and possibly be involved in the pathogenesis of this disease, because the virus may actively infect the enteroglial cells of the myenteric plexuses of the patients with chronic idiopathic intestinal pseudo-obstruction. We report two cases of upper idiopathic intestinal pseudo-obstruction associated with JCV infection.

Indexed as

JC VirusDuodenal DiseasesDuodenoscopyFemaleHumansIntestinal Pseudo-ObstructionMaleMiddle AgedPolyomavirus InfectionsTumor Virus InfectionsChronic idiopathic intestinal pseudo-obstructionGastrointestinal motility disordersJC virus

Identifiers

PMID31728918
OpenAlexW2983330595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.