Evidence map›Paper›PMID 31728837›Full record

ArticleJournal of nephrology2020

Cardiac MRI measurements of pericardial adipose tissue volumes in patients on in-centre nocturnal hemodialysis.

Sean Cai, Ron Wald, Djeven P Deva, Mercedeh Kiaii, Ming-Yen Ng, Gauri R Karur, Oblugbenga Bello, Zhuo Jun Li, Jonathon Leipsic, Laura Jimenez-Juan and 3 more

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00718848 (Impact of In-centre Nocturnal Hemodialysis on Ventricular Remodeling and Function in End-stage Renal Disease), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00718848 completednot on this map

Impact of In-centre Nocturnal Hemodialysis on Ventricular Remodeling and Function in End-stage Renal Disease

TypeobservationalSponsorUnity Health TorontoRan2008 to 2012Enrolled67ConditionsEnd-stage Renal Disease, Left Ventricular HypertrophyArmsIncentre nocturnal hemodialysis, Remaining on conventional hemodialysis
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Observational
  2. Cardiovascular Biomarkers in Nocturnal Hemodialysis and Their Association With Physical Performance.Hemodialysis international. International Symposium on Home Hemodialysis · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Sean CaiDepartment of Medicine, University of Toronto, Toronto, Canada.
Ron WaldDepartment of Medicine, University of Toronto, Toronto, Canada.
Djeven P DevaDepartment of Medical Imaging, St Michael's Hospital, University of Toronto, Toronto, Canada.
Mercedeh KiaiiDivision of Nephrology, St. Paul's Hospital, Vancouver, Canada.
Ming-Yen NgDepartment of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China.
Gauri R KarurToronto Joint Department of Medical Imaging, University Health Network, Toronto, Canada.
Oblugbenga BelloDivision of Cardiology, St. Michael's Hospital, 30 Bond Street, Donnelly 6-034, Toronto, ON, M5B 1W8, Canada.
Zhuo Jun LiDivision of Cardiology, St. Michael's Hospital, 30 Bond Street, Donnelly 6-034, Toronto, ON, M5B 1W8, Canada.
Jonathon LeipsicDepartment of Medical Imaging, St Paul's Hospital, Vancouver, Canada.
Laura Jimenez-JuanDepartment of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Anish KirpalaniDepartment of Medical Imaging, St Michael's Hospital, University of Toronto, Toronto, Canada.
Kim A ConnellyDepartment of Medicine, University of Toronto, Toronto, Canada.
Andrew T YanDepartment of Medicine, University of Toronto, Toronto, Canada. andrew.yan@unityhealth.to.ORCID http://orcid.org/0000-0002-2063-7485
St. Michael's Hospital · CASt. Paul's Hospital · CASunnybrook Health Science Centre · CAUniversity Health Network · CAUniversity of Hong Kong · HKUniversity of Toronto · CA

Funding

CIHR ClinicalTrials.gov Identifier: NCT00718848Heart and Stroke Foundation of Canada Grant-in-Aid
6 · The paper itself

Abstract

backgroundConversion from conventional hemodialysis (CHD) to in-centre nocturnal hemodialysis (INHD) is associated with left ventricular (LV) mass regression, but the underlying mechanisms are not fully understood. Using cardiac MRI (CMR), we examined the effects of INHD on epicardial adipose tissue (EAT) and paracardial adipose tissue (PAT), and the relationships between EAT, PAT and LV remodeling, biomarkers of nutrition, myocardial injury, fibrosis and volume.

methodsWe conducted a prospective multicenter cohort study of 37 patients transitioned from CHD to INHD and 30 patients on CHD (control). Biochemical markers and CMR were performed at baseline and 52 weeks. CMR images were analyzed by independent readers, blinded to order and treatment group.

resultsAmong 64 participants with complete CMR studies at baseline (mean age 54; 43% women), there were no significant differences in EAT index (60.6 ± 4.3 mL/m

conclusionsINHD was not associated with any changes in EAT index and PAT index over 12 months. Changes in EAT index were not significantly associated with changes in markers of LV remodeling, nutrition, myocardial injury, fibrosis, volume status. In contrast, changes in PAT index, which paradoxically is expected to exert less paracrine effect on the myocardium, were correlated with changes in LVESVI, LVMI and LVEF. Larger and longer-term studies may clarify the role of PAT in cardiac remodeling with intensified hemodialysis. CLINICALTRIALS. GOV IDENTIFIER: NCT00718848.

Indexed as

Renal DialysisAdipose TissueAdultAgedCohort StudiesFemaleFibroblast Growth Factor-23HumansKidney Failure, ChronicMagnetic Resonance ImagingMaleMiddle AgedNutritional StatusPericardiumVentricular RemodelingFibroblast Growth Factor-23Cardiac MRIDialysisEpicardial fatVentricular remodeling

Identifiers

PMID31728837
OpenAlexW2986484494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.