Evidence map›Paper›PMID 31728739›Full record

ReviewCurrent oncology reports2019

Chronic Myelomonocytic Leukemia: Insights into Biology, Prognostic Factors, and Treatment.

Giacomo Coltro, Mrinal M Patnaik

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Allogeneic Transplant for CMML.Current hematologic malignancy reports · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Myeloproliferative Neoplasms with Monocytosis.Current hematologic malignancy reports · 2022
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Giacomo ColtroDepartment of Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Mrinal M PatnaikDepartment of Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. patnaik.mrinal@mayo.edu.
Mayo Clinic · USWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewChronic myelomonocytic leukemia (CMML) is a clonal hematological malignancy characterized by both dysplastic and proliferative features, with an inherent risk for leukemic transformation. With the help of this review, we aim to summarize key concepts with regards to CMML biology, diagnosis, risk stratification, and therapeutics. RECENT

findingsBased on recent studies, CMML is hallmarked by a relatively low genetic complexity, which contrasts with a compelling phenotypical heterogeneity, largely driven by epigenetic mechanisms. Recent advances in the characterization of CMML biology has led to an improvement in risk-stratification, by means of incorporating prognostically relevant gene mutations. This, however, has not significantly impacted available therapies and outcomes continue to remain poor. Advances in CMML biology have better explained the phenotypic heterogeneity, while continuing to define the genetic and epigenetic landscape. In spite of recent advances, limited effective therapies exist and developing rationally derived therapeutic approaches is much needed.

Indexed as

Abnormal KaryotypeAntineoplastic AgentsEpigenesis, GeneticHematopoietic Stem Cell TransplantationHumansLeukemia, Myelomonocytic, ChronicMolecular Targeted TherapyMutationPrognosisAntineoplastic AgentsChronic myelomonocytic leukemiaClonal architectureMyelodysplastic syndromesMyeloproliferative neoplasmsPrognosticationTarget therapy

Identifiers

PMID31728739
OpenAlexW2988995732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.