Evidence map›Paper›PMID 31728738›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2019

Biometals as conformational modulators of α-synuclein photochemical crosslinking.

Dinendra L Abeyawardhane, Alyson M Curry, Ashley K Forney, Joel W Roberts, Heather R Lucas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Cross-Linked α-Synuclein as Inhibitor of Amyloid Formation.International journal of molecular sciences · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dinendra L AbeyawardhaneDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Alyson M CurryDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Ashley K ForneyDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Joel W RobertsDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Heather R LucasDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284, USA. hrlucas@vcu.edu.ORCID 0000-0003-1207-7550
Virginia Commonwealth University · US

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Alpha-Synuclein Assemblies and Metal-Mediated Redox MechanismsR01GM134015 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI LUCAS, HEATHER R · 2019 to 2023
$1.7M
NCATS NIH HHS UL1 TR002649NCATS NIH HHS UL1TR002649NIGMS NIH HHS R01 GM134015
6 · The paper itself

Abstract

Metal dyshomeostasis has long been linked to Parkinson's disease (PD), and the amyloidogenic protein α-synuclein (αS) is universally recognized as a key player in PD pathology. Structural consequences upon coordination of copper and iron to αS have gained attention due to significant dyshomeostasis of both metals in the PD brain. Protein-metal association can navigate protein folding in distinctive pathways based on the identity of the bio-metal in question. In this work, we employed photo-chemical crosslinking of unmodified proteins (PICUP) to evaluate these potential metal ion-induced structural alterations in the folding dynamics of N-terminally acetylated αS (

Indexed as

alpha-SynucleinAmmonium SulfateCoordination ComplexesCopperCross-Linking ReagentsFluorescenceIronLightOrganometallic CompoundsOxidation-ReductionPhotochemical ProcessesPhotosensitizing AgentsProtein BindingProtein ConformationRuthenium CompoundsTyrosinealpha-Synucleinammonium peroxydisulfateAmmonium SulfateCoordination ComplexesCopperCross-Linking ReagentsdityrosineIronOrganometallic CompoundsPhotosensitizing AgentsRuthenium Compoundstris(2,2-bipyridine)-ruthenium(II)TyrosineCopperDityrosineIronPhotochemical crosslinkingα-Synuclein

Identifiers

PMID31728738
PMCPMC7334974
OpenAlexW2987561640

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.