Evidence map›Paper›PMID 31728727›Full record

ReviewMedical molecular morphology2020

Primary mediastinal large B cell lymphoma with coexisting aberrations of C-MYC and BCL-2: a case report and literature review.

Yanyan Jiang, Wenbin Mo, Yuan Miao, Ying Liang, Yan Li, Rui Zhang

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Medical molecular morphology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Prognostic significance of clinical characteristics andThe Journal of international medical research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yanyan JiangDepartment of Hematology, The First Affiliated Hospital of China Medical University, No.155, Nanjing North Street, Shenyang, 110001, Liaoning, People's Republic of China.
Wenbin MoDepartment of Hematology, The First Affiliated Hospital of China Medical University, No.155, Nanjing North Street, Shenyang, 110001, Liaoning, People's Republic of China.
Yuan MiaoDepartment of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, 110001, Liaoning, People's Republic of China.
Ying LiangDepartment of Hematology, The First Affiliated Hospital of China Medical University, No.155, Nanjing North Street, Shenyang, 110001, Liaoning, People's Republic of China.
Yan LiDepartment of Hematology, The First Affiliated Hospital of China Medical University, No.155, Nanjing North Street, Shenyang, 110001, Liaoning, People's Republic of China.
Rui ZhangDepartment of Hematology, The First Affiliated Hospital of China Medical University, No.155, Nanjing North Street, Shenyang, 110001, Liaoning, People's Republic of China. hemozerro2008@hotmail.com.
First Hospital of China Medical University · CNChina Medical University · CN

Funding

the National Natural Science Foundation of China 81600117
6 · The paper itself

Abstract

Primary mediastinal large B-cell lymphoma (PMLBCL) is an aggressive lymphoma characteristic with distinct clinical, morphologic, and immunophenotypic features. The rearrangements of C-MYC, BCL2 and/or BCL6 which are common in diffuse large B-cell lymphoma (DLBCL) are typically absent in PLMBCL. Here we proved a novel case of PMLBCL with concurrent rearrangements of C-MYC and BCL2. Histology showed typical pathomorphological features of PLMBCL. Fluorescent in situ hybridization (FISH) studies showed rearrangements of C-MYC and copy number variation (CNV) of BCL2 gene. It is not well known on the clinical significance of rearrangements of C-MYC and BCL2 genes in PMLBCL. The case gives evidence that cytogenetic testing is necessary for PMLBCLs to get precise clinical evaluation and appropriate treatment.

Indexed as

Stem Cell TransplantationAntineoplastic Combined Chemotherapy ProtocolsBiopsy, Large-Core NeedleCombined Modality TherapyDNA Copy Number VariationsGene RearrangementHumansLung NeoplasmsLymphoma, Large B-Cell, DiffuseMaleMediastinal NeoplasmsMediastinumPositron Emission Tomography Computed TomographyProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mycTransplantation, AutologousBCL2 protein, humanMYC protein, humanProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mycBCL2C-MYCCopy number variationGene rearrangementPrimary mediastinal large B-cell lymphoma

Identifiers

PMID31728727
OpenAlexW2983230907

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.