ArticleEuropean journal of nutrition2020
Macronutrient intake and frailty: the Rotterdam Study.
Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Carbohydrate-to-fat ratio is positively associated with comprehensive frailty across protein-intake levels in older adults.European journal of nutrition · 2026Article
- Association between dietary protein intake and frailty index among home-dwelling older adults; an 8-year follow-up study.The journal of nutrition, health & aging · 2026Article
- The (ab)use of food frequency questionnaire data in substitution modelling in nutritional epidemiology: a critique.European journal of clinical nutrition · 2026Review
- BMI Mediates the Association between Macronutrient Subtypes and Phenotypic Age Acceleration.Nutrients · 2024Article
- Nutrition and frailty: additional evidence supporting their relationships.The journal of nutrition, health & aging · 2024Article
- Relationship between dietary macronutrients intake and biological aging: a cross-sectional analysis of NHANES data.European journal of nutrition · 2024Article
- Moderate protein intake percentage in mice for maintaining metabolic health during approach to old age.GeroScience · 2023Article
- Associations between Low-Carbohydrate Diets and Low-Fat Diets with Frailty in Community-Dwelling Aging Chinese Adults.Nutrients · 2023Article
- Protocol for the FACE study: frailty and comorbidity in elderly patients-a multicenter, Chinese observational cohort study.Journal of geriatric cardiology : JGC · 2023Article
- Article
- Changes in Dietary Total and Nonheme Iron Intake Is Associated With Incident Frailty in Older Men: The Concord Health and Aging in Men Project.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Relationship between Dietary Macronutrients Intake and the ATHLOS Healthy Ageing Scale: Results from the Polish Arm of the HAPIEE Study.Nutrients · 2022Article
- Fatty Acids and Frailty: A Mendelian Randomization Study.Nutrients · 2021Article
- Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management.Frontiers in nutrition · 2021Review
- Dietary Protein, Exercise, and Frailty Domains.Nutrients · 2019Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo investigate the longitudinal association between the macronutrient composition of the diet and frailty.
methodsData were obtained from 5205 Dutch middle-aged and older adults participating in the Rotterdam Study. Frailty was measured using a frailty index based on the accumulation of 38 health-related deficits, score between 0 and 100, and a higher score indicating more frailty. Frailty was assessed at baseline and 11 years later (range of 23 years). Macronutrient intake was assessed using food-frequency questionnaires. The association between macronutrients and frailty over time was evaluated using multivariable linear regression, adjusted for the frailty index at baseline, energy intake, and other relevant confounders. All analyses were performed in strata of BMI.
resultsMedian frailty index score was 13.8 points (IQR 9.6; 19.1) at baseline and increased by a median of 2.3 points (IQR - 2.0; 7.6) after 11 years. Overall, we found no significant associations between intake of carbohydrates or fat and frailty over time. We did observe a significant positive association between an iso-energetic intake of 10 g protein and frailty over time (β 0.31 (95% CI 0.06; 0.55)) which was mainly driven by animal protein (β 0.31 (95% CI 0.07; 0.56)). It did not depend on whether it was substituted fat or carbohydrates.
conclusionsOur findings suggest that a reduction in the intake of animal protein may improve the overall health status over time in a relatively healthy population. More research is needed on the optimal macronutrient composition of the diet and frailty in more vulnerable populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.