Evidence map›Paper›PMID 31728675›Full record

Trial reportEuropean journal of pediatrics2020

Repeating a dose of sucrose for heel prick procedure in preterms is not effective in reducing pain: a randomised controlled trial.

Paola Lago, Maria Elena Cavicchiolo, Teresa Mion, Valentina Dal Cengio, Antonella Allegro, Marco Daverio, Anna Chiara Frigo

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
8.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Sucrose analgesia for heel-lance procedures in neonates.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Non-pharmacological management of infant and young child procedural pain.The Cochrane database of systematic reviews · 2023
    Pooled it
  4. Trial
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Paola LagoNeonatal Intensive Care Unit, Department of Woman and Child Health, University of Padua, Via Giustiniani 3, 35128, Padua, Italy.
Maria Elena CavicchioloNeonatal Intensive Care Unit, Department of Woman and Child Health, University of Padua, Via Giustiniani 3, 35128, Padua, Italy. mecavicchiolo@gmail.com.ORCID http://orcid.org/0000-0002-9965-6549
Teresa MionNeonatal Intensive Care Unit, Department of Woman and Child Health, University of Padua, Via Giustiniani 3, 35128, Padua, Italy.
Valentina Dal CengioNeonatal Intensive Care Unit, San Bortolo Hospital, Vicenza, Italy.
Antonella AllegroNeonatal Intensive Care Unit, Department of Woman and Child Health, University of Padua, Via Giustiniani 3, 35128, Padua, Italy.
Marco DaverioPaediatric Intensive Care Unit, Department of Woman and Child Health, University of Padua, Padua, Italy.
Anna Chiara FrigoDepartment of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padua, Italy.
University of Padua · ITOspedale San Bortolo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral sucrose is included in almost all recommendations for treatment of pain in newborns, but evidence if multiple doses might be more effective than a single standard dose is lacking. We designed a single-centre, double-blind, randomised, controlled trial. We enrolled preterm infants needing the heel prick procedure. Each enrolled infant was randomised to receive a single standard dose of sucrose 2 min before or a double dose of sucrose 2 min before, and 30 s after heel prick. Primary outcome was the efficacy of the two interventions tested by the premature infant pain profile-PIPP scale obtained at 30 s, 60 s, and 120 s after heel prick. Secondary outcome was the evaluation of the concordance between the PIPP scale and other pain scores more feasible in clinical practice. Seventy-two infants were randomised. No difference in pain perception as measured by the PIPP scale was found between the groups: median PIPP values 4.0(IQR 3.0-4.0) vs 3.0(IQR 3.0-4.0) at baseline; 6.0(IQR 5.0-10.0) vs 6.0(IQR 4.0-8.5) at 30 s; 6.0(IQR 4.0-7.0) vs 5.0(IQR 4.0-8.5) at 60 s and 5.0(IQR 4.0-7.0) vs 5.0(IQR 4.0-7.5) at 2 min, in the experimental and standard treatment groups, respectively (p = 0.9020). There was no correlation between PIPP scores and other pain scales.Conclusion: We do not recommend doubling the dose during heel prick.What is Known:• Oral sucrose is included in almost all international position papers and recommendations for the treatment of mild to moderate pain in newborns, associated with non-nutritive sucking and facilitated tucking• Premature infant pain profile (PIPP) scale is the gold standard for evaluation of pain in preterms but it is difficult to use in clinical practiceWhat is New:• Repeating a dose of 24% sucrose is not effective in reducing pain during the recovery phase of a skin breaking procedure• Other pain scales, easier to use in clinical practice, are not comparable with PIPP for the evaluation of procedural pain in preterms.

Indexed as

Infant, PrematureIntensive Care Units, NeonatalAdministration, OralChi-Square DistributionDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleFemaleHeelHumansInfant, NewbornItalyMaleNeedlesObserver VariationPainSucroseFacilitated tuckingHeel prickNon-nutritive suckingPainPreterm infantSucrose

Identifiers

PMID31728675
OpenAlexW2983129763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.