Evidence map›Paper›PMID 31728580›Full record

ReviewCellular and molecular life sciences : CMLS2020

The link between endometrial stromal cell senescence and decidualization in female fertility: the art of balance.

Pavel Deryabin, Anastasiia Griukova, Nikolay Nikolsky, Aleksandra Borodkina

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06280560 (Impact of Controlled Ovarian Stimulation and Luteal Phase Support on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation), which is not on this map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06280560 recruitingnot on this mapstarted 2024, after this paper: background citation

Impact of Controlled Ovarian Stimulation and Luteal Phase Support on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation: Pilot Study

Typeobservational_patient_registrySponsorFundación IVIRan2024 to 2025Enrolled60ConditionsEndometrial ReceptivityArmsControlled Ovarian Stimulation + Luteal Phase Support, Hormonal Replacement Therapy programmed artificial cycle, Natural Cycle (NC), Endometrial receptivity reference group
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 85 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Pavel DeryabinDepartment of Intracellular Signaling and Transport, Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064, St-Petersburg, Russia.
Anastasiia GriukovaDepartment of Intracellular Signaling and Transport, Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064, St-Petersburg, Russia.
Nikolay NikolskyDepartment of Intracellular Signaling and Transport, Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064, St-Petersburg, Russia.
Aleksandra BorodkinaDepartment of Intracellular Signaling and Transport, Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064, St-Petersburg, Russia. borodkina618@gmail.com.ORCID http://orcid.org/0000-0003-1675-7588
Institute of Cytology · RU

Funding

Russian Science Foundation 19-74-10038
6 · The paper itself

Abstract

Cell senescence seems to be an ambivalent biological phenomenon in many aspects. At the cellular level it is considered as an irreversible cell-cycle arrest commonly caused by the DNA damage. Senescent cells harbor a lot of impairments in various intracellular systems. Presence of senescent cells within tissues should ultimately lead to their malfunctioning. However, the interlink between cellular senescence and tissue/organismal functioning is far from always being unidirectional. The entangled and complex relationship between senescence and tissue-specific decidual differentiation of endometrial stromal cells (ESCs) is the excellent example reflecting dualism of cellular senescence. ESCs decidualization conditions endometrium responsiveness to embryonic signals and plays a critical role in embryo biosensoring, selection and implantation. Based on the analysis of the existing literary data, here we will try (1) to puzzle out how cellular senescence simultaneously may be an integral part of normal decidualization and may be involved in the progression of repeated implantation failures and recurrent pregnancy losses; (2) to suppose the sequence of cellular events reflecting the role of ESCs' senescence during normal and impaired decidualization. Together, the deep scan of the interlink between ESCs' senescence and decidualization will allow to suggest the preferable application scheme for senolytics targeting senescent cells as a possible approach to restore impaired endometrial receptivity and thus to increase the effectiveness of in vitro fertilization cycles.

Indexed as

Cellular SenescenceAnimalsEmbryonic Stem CellsEndometriumFemaleFertilityHumansReproductionStromal CellsCell agingMesenchymal stromal cellsReproductionTissue-specific differentiation

Identifiers

PMID31728580
PMCPMC11104872
OpenAlexW2985077279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.