Evidence map›Paper›PMID 31728565›Full record

ArticleDiabetologia2020

Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study.

Markus Mattila, Iris Erlund, Hye-Seung Lee, Sari Niinistö, Ulla Uusitalo, Carin Andrén Aronsson, Sandra Hummel, Hemang Parikh, Stephen S Rich, William Hagopian and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  18. Type 1 diabetes mellitus prevention.Pediatric endocrinology, diabetes, and metabolism · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 4 countries.

Markus MattilaFaculty of Social Sciences/Health Sciences, Tampere University, Tampere, Finland.
Iris ErlundDepartment of Public Health Solutions, National Institute for Health and Welfare, PO Box 30, FI-00271, Helsinki, Finland.
Hye-Seung LeeHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Sari NiinistöDepartment of Public Health Solutions, National Institute for Health and Welfare, PO Box 30, FI-00271, Helsinki, Finland.
Ulla UusitaloHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Carin Andrén AronssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Sandra HummelInstitute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.
Hemang ParikhHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
William HagopianPacific Northwest Research Institute, Seattle, WA, USA.
Jorma ToppariDepartment of Pediatrics, Turku University Hospital, Turku, Finland.
Åke LernmarkDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Anette G ZieglerInstitute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.
Marian RewersBarbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.
Jeffrey P KrischerHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA.
Suvi M VirtanenFaculty of Social Sciences/Health Sciences, Tampere University, Tampere, Finland. suvi.virtanen@thl.fi.ORCID http://orcid.org/0000-0001-8928-0878
TEDDY Study Group
University of South Florida · USLund University · SEColorado School of Public Health · USPacific Northwest Diabetes Research Institute · USTampere University · FIFinnish Institute for Health and Welfare · FITUM Klinikum · DEUniversity of Turku · FI

Funding

Data Coordinating Center (DCC)for the Consortium for Identification of EnvironmenUC4DK095300 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2011 to 2011
$56.0M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
NIDDK Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)UC4DK117483 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2017 to 2020
$30.4M
Establish a Data Coordinating Center (DCC) for the Consortium for Identification UC4DK100238 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2014
$28.9M
The Study of Epigenetics and Infections in The Environmental Determinants of Diabetes in the Young (TEDDY)UC4DK112243 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2016 to 2016
$27.0M
Data Coordinating Center (DCC) for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY) StudyUC4DK106955 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2015 to 2015
$20.0M
The Environmental Determinants of Diabetes in Young (TEDDY0U01DK063863 · NIDDK · HOSPITAL DISTRICT OF SOUTHWEST FINLAND · PI TOPPARI, JORMA · 2003 to 2022
$13.5M
THE TEDDY STUDY - COLORADO CLINICAL CENTERU01DK063821 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 2003 to 2022
$12.3M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
The Environmental Determinants of Diabetes in the Young (TEDDY) StudyUC4DK063863 · NIDDK · HOSPITAL DISTRICT OF SOUTHWEST FINLAND · PI TOPPARI, JORMA · 2013 to 2013
$5.6M
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001082NIDDK NIH HHS U01 DK063821NIDDK NIH HHS U01 DK063863NIDDK NIH HHS UC4 DK063863NIDDK NIH HHS UC4 DK095300NIDDK NIH HHS UC4 DK100238NIDDK NIH HHS UC4 DK106955NIDDK NIH HHS UC4 DK112243NIDDK NIH HHS UC4 DK117483NLM NIH HHS HHSN267200700014C
6 · The paper itself

Abstract

aims/hypothesisWe studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes.

methodsWe used a risk set sampled nested case-control design within an ongoing international multicentre observational study: The Environmental Determinants of Diabetes in the Young (TEDDY). The TEDDY study followed children with increased genetic risk from birth to endpoints of islet autoantibodies (350 cases, 974 controls) and type 1 diabetes (102 cases, 282 controls) in six clinical centres. Control participants were matched for family history of type 1 diabetes, clinical centre and sex. Plasma ascorbic acid concentration was measured at ages 6 and 12 months and then annually up to age 6 years. SNPs in vitamin C transport genes were genotyped using the ImmunoChip custom microarray. Comparisons were adjusted for HLA genotypes and for background population stratification.

resultsChildhood plasma ascorbic acid (mean ± SD 10.76 ± 3.54 mg/l in controls) was inversely associated with islet autoimmunity risk (adjusted OR 0.96 [95% CI 0.92, 0.99] per +1 mg/l), particularly islet autoimmunity, starting with insulin autoantibodies (OR 0.94 [95% CI 0.88, 0.99]), but not with type 1 diabetes risk (OR 0.93 [95% Cl 0.86, 1.02]). The SLC2A2 rs5400 SNP was associated with increased risk of type 1 diabetes (OR 1.77 [95% CI 1.12, 2.80]), independent of plasma ascorbic acid (OR 0.92 [95% CI 0.84, 1.00]). CONCLUSIONS/

interpretationHigher plasma ascorbic acid levels may protect against islet autoimmunity in children genetically at risk for type 1 diabetes. Further studies are warranted to confirm these findings. DATA AVAILABILITY: The datasets generated and analysed during the current study will be made available in the NIDDK Central Repository at https://www.niddkrepository.org/studies/teddy.

Indexed as

Ascorbic AcidAutoimmunityCase-Control StudiesChildChild, PreschoolDiabetes Mellitus, Type 1FemaleGenetic Predisposition to DiseaseGenotypeGlucose Transporter Type 2HumansInfantMalePolymorphism, Single NucleotideRisk FactorsAscorbic AcidGlucose Transporter Type 2SLC2A2 protein, humanAutoimmunityPlasma ascorbic acidSingle nucleotide polymorphismSNPTransporter genesType 1 diabetesVitamin C

Identifiers

PMID31728565
PMCPMC6946743
OpenAlexW2987770734

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.