Evidence map›Paper›PMID 31728520›Full record

ArticleInflammatory bowel diseases2020

The Incidence and Prevalence of Anxiety, Depression, and Post-traumatic Stress Disorder in a National Cohort of US Veterans With Inflammatory Bowel Disease.

Elyse R Thakur, Shubhada Sansgiry, Jennifer R Kramer, Akbar K Waljee, Jill K Gaidos, Linda A Feagins, Shail M Govani, Lilian Dindo, Hashem B El-Serag, Jason K Hou

Open access · hybridAbstract read
In one paragraph

Article in Inflammatory bowel diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Risk of autoimmune diseases after post-traumatic stress disorder: a nationwide cohort study.European archives of psychiatry and clinical neuroscience · 2024
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  11. Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  12. Effect of Huanglian Decoction on the Intestinal Microbiome in Stress Ulcer (SU) Mice.Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Elyse R ThakurFrom theVA South Central Mental Illness Research, Education and Clinical Center, Houston, TX, USA.
Shubhada SansgiryFrom theVA South Central Mental Illness Research, Education and Clinical Center, Houston, TX, USA.
Jennifer R KramerVA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
Akbar K WaljeeVA Center for Clinical Management Research, VA Ann Arbor Health Care System, Ann Arbor, MI, USA.
Jill K GaidosVirginia Commonwealth University and Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, USA.
Linda A FeaginsDepartment of Internal Medicine, VA North Texas Health Care System, and The University of Texas Southwestern Medicine Center at Dallas, Dallas, TX, USA.
Shail M GovaniSouth Texas Veterans Health Care System and UT Health San Antonio, San Antonio, Texas USA.
Lilian DindoVA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
Hashem B El-SeragVA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
Jason K HouMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Michael E. DeBakey VA Medical Center · USBaylor College of Medicine · USCenter for Innovation · USHunter Holmes McGuire VA Medical Center · USMichigan Medicine · USSouth Texas Veterans Health Care System · USVA North Texas Health Care System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

backgroundPatients with inflammatory bowel disease (IBD) are more susceptible to mental health problems than the general population; however, temporal trends in psychiatric diagnoses' incidence or prevalence in the United States are lacking. We sought to identify these trends among patients with IBD using national Veterans Heath Administration data.

methodsWe ascertained the presence of anxiety, depression, or posttraumatic stress disorder among veterans with IBD (ulcerative colitis or Crohn's disease) during fiscal years 2000-2015. Patients with prior anxiety, depression, or posttraumatic stress disorder before their first Veterans Health Administration IBD encounter were excluded to form the study cohort. We calculated annual prevalence, incidence rates, and age standardized and stratified by gender using a direct standardization method.

resultsWe identified 60,086 IBD patients (93.9% male). The prevalence of anxiety, depression, and/or posttraumatic stress disorder increased from 10.8 per 100 with IBD in 2001 to 38 per 100 with IBD in 2015; 19,595 (32.6%) patients had a new anxiety, depression, and/or posttraumatic stress disorder diagnosis during the study period. The annual incidence rates of these mental health problems went from 6.1 per 100 with IBD in 2001 to 3.6 per 100 in 2015. This trend was largely driven by decline in depression.

conclusionsThe prevalence of anxiety, depression, and posttraumatic stress disorder is high among US veterans with IBD and increasing, given the chronicity of IBD and psychological diagnoses. Incidence, particularly depression, appears to be declining. Confirmation and reasons for this encouraging trend are needed.

Indexed as

AgedAnxietyColitis, UlcerativeCrohn DiseaseDepressionFemaleHumansIncidenceInflammatory Bowel DiseasesMaleMiddle AgedPrevalenceStress Disorders, Post-TraumaticUnited StatesVeteransanxietydepressioninflammatory bowel diseaseposttraumatic stress disorderveterans

Identifiers

PMID31728520
PMCPMC7441098
OpenAlexW2984824909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.