ReviewInternational journal of nursing sciences2019
Oxytocin and early parent-infant interactions: A systematic review.
Review in International journal of nursing sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05402787 (The Effect of Virtual Visit to Mothers With Infants in the Neonatal Intensive Care Unit on Mothers' Attachment and Satisfaction), which is not on this map. Cited by 75 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Virtual Visit to Mothers With Infants in the Neonatal Intensive Care Unit on Mothers' Attachment and Satisfaction
Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.
- Moral judgment and hormones: A systematic literature review.PloS one · 2022Pooled it
- Reduction of oxytocin plasma levels in borderline personality disorder and normalization induced by psychotherapies.Psychological medicine · 2025Trial
- Skin-to-Skin Contact at Birth for Very Preterm Infants and Mother-Infant Interaction Quality at 4 Months: A Secondary Analysis of the IPISTOSS Randomized Clinical Trial.JAMA network open · 2023Trial
- The effects of a music enrichment program on parent-infant interactions during mealtime: A randomized controlled trial.Appetite · 2023Trial
- Cohort Profile: The Ecuadorian National Birth and Infant Nutrition cohort.International journal of epidemiology · 2026Article
- Limited nesting stress in mice as a model to study neuroimmune relationships in postpartum depression.Journal of neuroendocrinology · 2026Article
- Predicting Positive Affect in Infancy.Developmental science · 2026Article
- Families Implementing Resilient Systems Together (FIRST).Children (Basel, Switzerland) · 2026Article
- Infant Temperament, Breastfeeding, and Sleep at 6 and 14 Months.Children (Basel, Switzerland) · 2026Article
- Short-term maternal outcomes after intraoperative administration of prophylactic oxytocin during cesarean sections: a retrospective cohort study with a comparison of different administration protocols.Archives of gynecology and obstetrics · 2026Article
- Attachment Theory: Novel Clinical and Molecular Insights.Biomolecules · 2026Review
- Associations of parental labour migration and childhood maltreatment with psychosocial health among adolescents and young adults in China.European journal of psychotraumatology · 2025Article
- Gestational stress disrupts the neuroimmune environment in the nucleus accumbens of maternal rats.Brain, behavior, & immunity - health · 2025Article
- Tactile stimulation reverses painful stimuli outcomes via PVN-VTA oxytocin circuitry and dopaminergic regulation.Communications biology · 2025Article
- The role of oxytocin as an indicator of outcome and therapeutic alliance.Research in psychotherapy (Milano) · 2025Article
- Associations of Hair Biomarkers with Height, Weight, and Body Mass Index in Preschool Children.Children (Basel, Switzerland) · 2025Article
- The prospective association of prenatal anxiety symptoms in mothers and fathers with general child development 14 months postpartum and the mediating role of parent-child bonding: a mediation analysis within the longitudinal cohort study DREAM.BMC pregnancy and childbirth · 2025Article
- Effects of Intranasal Oxytocin Across Various Depressive Disorders.Psychiatry investigation · 2025Article
- Article
- Maternal Thyroid Supplementation Prevents Autistic-relevant Social Behavior and Hypothalamic Oxytocin Depletion Produced by Developmental Exposure to Environmental Toxicants.bioRxiv : the preprint server for biology · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesSocial relationships throughout lifespan are critical for health and wellbeing. Oxytocin, often called the 'hormone of attachment' has been suggested as playing an important role in early-life nurturing and resulting social bonding. The objective of this paper is to synthesize the associations between oxytocin levels and interactions between infants and parents that may trigger oxytocin release, and in turn facilitate attachments.
methodsA comprehensive cross-disciplinary systematic search was completed using electronic databases. The inclusion criteria included studies that focused on mother-infant and father-infant interaction and measured both baseline and post-interaction oxytocin levels.
resultsSeventeen studies were included in the final systematic review. The reviewed studies used mother-infant and/or father-infant play and skin-to-skin contact between maternal-infant and paternal-infant dyads to examine the oxytocin role in early life bonding and parenting processes. Studies showed a positive correlation between parent-infant contact and oxytocin levels in infancy period. Increased maternal oxytocin levels were significantly related to more affectionate contact behaviors in mothers following mother-infant contact, synchrony, and engagement. Meanwhile, increased paternal oxytocin levels were found to be related to more stimulatory contact behaviors in fathers following father-infant contact. Oxytocin levels significantly increased in infants, mothers and fathers during skin-to-skin contact and parents with higher oxytocin levels exhibited more synchrony and responsiveness in their infant interactions.
conclusionThe review suggests that oxytocin plays an important role in the development of attachment between infants and parents through early contact and interaction. The complexities of oxytocinergic mechanisms are rooted in neurobiological, genetic, and social factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.