ReviewAnnals of translational medicine2019
Lessons learned in acute respiratory distress syndrome from the animal laboratory.
Review in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Ventilator-induced lung injury in rat models: are they all equal in the race?Laboratory animal research · 2025Review
- Experimental animal models of acute respiratory distress syndrome: one-hit and two-hit establishment application.Frontiers in immunology · 2025Review
- Article
- A novel tree shrew model of lipopolysaccharide-induced acute respiratory distress syndrome.Journal of advanced research · 2024Article
- SARS-CoV-2-Infection (COVID-19): Clinical Course, Viral Acute Respiratory Distress Syndrome (ARDS) and Cause(s) of Death.Medical sciences (Basel, Switzerland) · 2022Review
- A new mouse unilateral model of diffuse alveolar damage of the lung.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- Validation of Messenger Ribonucleic Acid Markers Differentiating Among Human Acute Respiratory Distress Syndrome Subgroups in an Ovine Model of Acute Respiratory Distress Syndrome Phenotypes.Frontiers in medicine · 2022Article
- Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: An experimental ovine study.Physiological reports · 2021Article
- Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice.Pharmaceutics · 2021Article
- Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps.Critical care (London, England) · 2021Article
- Description of ovine model for testing ventilator prototypes in the COVID-19 pandemic.Revista espanola de anestesiologia y reanimacion · 2020Article
- Systems Biology ARDS Research with a Focus on Metabolomics.Metabolites · 2020Review
- Publication trends of research on acute lung injury and acute respiration distress syndrome during 2009-2019: a 10-year bibliometric analysis.American journal of translational research · 2020Article
- A focused issue on pediatric acute respiratory distress syndrome.Annals of translational medicine · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Since the description of the acute respiratory distress syndrome (ARDS) in 1967, investigators have struggled to reproduce the syndrome in the animal laboratory. While several different models of experimental acute lung injury (ALI) have been developed, none completely capture the inciting etiologies, initial inflammation, heterogeneity, and resolution of human ARDS. This potentially has contributed to the poor translation of potential therapeutics between animal ALI models and human ARDS. It was only recently that standardized criteria were suggested for what makes an ALI model comparable to human ARDS. Nevertheless, despite model heterogeneity, these models have contributed substantially to our understanding of the syndrome. From the initial studies identifying the risks of mechanical ventilation to the identification of potentially targetable inflammatory mediators, to modern studies focusing on regional heterogeneity and novel molecular pathways, animal models continue to inform our understanding of ARDS. This review will cover several major lessons learned from animal models of ALI, and provide some direction for future studies in this field.
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