ArticleJournal of research in pharmacy practice
Clinical Features, Treatment, Prognosis, and Mortality in Paraquat Poisonings: A Hospital-Based Study in Iran.
Article in Journal of research in pharmacy practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Clinical epidemiology and outcome of paraquat poisoning - A 12-year patient record based observational study.Journal of family medicine and primary care · 2026Article
- Systemic and Lung Inflammation and Oxidative Stress Associated With Behavioral Changes Induced by Inhaled Paraquat Are Ameliorated by Carvacrol.PPAR research · 2024Article
- Effects ofIranian journal of basic medical sciences · 2024Article
- Occupational respiratory disorders in Iran: a review of prevalence and inducers.Frontiers in medicine · 2024Review
- Molecular mechanism of paraquat-induced ferroptosis leading to pulmonary fibrosis mediated by Keap1/Nrf2 signaling pathway.Molecular biology reports · 2023Article
- Predicting mortality in paraquat poisoning through clinical findings, with a focus on pulmonary and cardiovascular system disorders.Journal of pharmaceutical policy and practice · 2023Article
- Andrographolide alleviates paraquat-induced acute lung injury by activating the Nrf2/HO-1 pathway.Iranian journal of basic medical sciences · 2023Article
- Sociodemographic and clinical characteristics related to the final condition of patients intoxicated by paraquat in a hospital in southwestern ColombiaBiomedica : revista del Instituto Nacional de Salud · 2022Observational
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- A novel simple risk model to predict the prognosis of patients with paraquat poisoning.Scientific reports · 2021Article
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- Inhibitory effect of pirfenidone on pulmonary fibrosis in patients with acute paraquat poisoning.American journal of translational research · 2021Article
- Study on the Efficacy and Safety of Ambroxol Combined with Methylprednisolone in Patients with Acute Lung Injury.BioMed research international · 2021Article
- Article
- Poisoning and Envenomation Induced Acute Kidney Injury: A Hospital-Based Study.Indian journal of nephrologyArticle
- Esophagitis dissecans superficialis associated with acute transoral paraquat poisoning: Clinical study of 15 cases.Science progressObservational
- Erratum: Clinical Features, Treatment, Prognosis, and Mortality in Paraquat Poisonings: A Hospital-based Study in Iran.Journal of research in pharmacy practiceArticle
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the present study was to evaluate the demographics, clinical characteristics, fatal dose, the efficacy of treatments, and prognosis in paraquat (PQ) poisoning in the Kerman Province of Iran.
methodsThis analytical cross-sectional study was conducted on 126 PQ poisoned patients who were referred to Afzalipour Hospital during 2006-2015. Demographic variables such as age and gender, signs and symptoms of poisoning, the estimated ingested dosage of PQ, and clinical outcome were extracted from medical records. Patients were compared and categorized into two groups considering the outcome: survivors and nonsurvivors. Patients with nonoral exposures, combined drug exposures, PQ exposures more than 24 h before the presentation, and critical underlying diseases were not included in the study.
findingsOur results indicated that the mean dose of PQ used by all patients was 2358 mg, which was reported as 1846 and 2812 mg in females and males, respectively. Moreover, the results showed that the highest mortality rate was in patients with respiratory distress, followed by oral ulceration and excess salivation. In all PQ-poisoned patients, the dose of greater than approximately 2250 mg predicted death with 86.2% specificity and 75.7% sensitivity.
conclusionBased on the results of the present study, the mortality rate in PQ-poisoned patients depended on the dose of poison, blood sugar level, and aspartate transaminase levels. Our results suggest that these parameters have excellent prognostic value for the prediction of mortality.
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