Evidence map›Paper›PMID 31728311›Full record

ArticleQuantitative imaging in medicine and surgery2019

Repeatability and reproducibility of prospective motion- and shim corrected 2D glycoCEST MRI.

Gizeaddis Lamesgin Simegn, Ali Alhamud, Andre J W van der Kouwe, Ernesta Meintjes, Frances Robertson

Abstract read
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026
    Review
  2. Recent developments in translational imaging of in vivo gene therapy outcomes.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gizeaddis Lamesgin SimegnSchool of Biomedical Engineering, Jimma Institute of Technology, Jimma University, Jimma, Ethiopia.
Ali AlhamudUCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Andre J W van der KouweUCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Ernesta MeintjesUCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Frances RobertsonUCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.

Funding

Longitudinal Neuroimaging and Cognitive Study of HIV-Infected ChildrenR01HD071664 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LAUGHTON, BARBARA, MEINTJES, ERNESTA MARIA · 2011 to 2015
$2.4M
Neonatal imaging as an early marker of neurodevelopment and predictor of cognitive performance in infants exposed to HIV and ART in utero and perinatallyR01HD085813 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LAUGHTON, BARBARA, MEINTJES, ERNESTA MARIA · 2016 to 2020
$2.3M
Longitudinal, multimodal analysis of HIV and ART effects on brain metabolism, structure and connectivity in young childrenR21MH108346 · NIMH · UNIVERSITY OF CAPE TOWN · PI BISWAL, BHARAT BHUSAN, MEINTJES, ERNESTA MARIA · 2015 to 2016
$298k
NICHD NIH HHS R01 HD071664NICHD NIH HHS R01 HD085813NIMH NIH HHS R21 MH108346
6 · The paper itself

Abstract

backgroundRepeated glycoCEST MRI measurements on the same subject should produce similar results under the same environmental and experimental conditions. However, fluctuations in the static B

methodsIn nine subjects, double volumetric navigated (DvNav)-CEST acquisitions in the calf muscle were repeated five times in each of two sessions-the first without correction, and the second with real-time shim- and motion correction applied. In both sessions a dynamically changing field was introduced by running a 5-minute gradient intensive diffusion sequence. We evaluated the effect of the introduced B

resultsWith real-time shim- and motion correction, glycoCEST results were relatively consistent with mean coefficient of variation (CoV) 2.7%±1.4% across all subjects, whereas without correction the results were less consistent with CoV 84%±71%.

conclusionsOur results demonstrate that real-time shim- and motion correction can mitigate effects of B0 field fluctuations and improve reproducibility of glycoCEST data. This is important when conducting longitudinal studies or when using glycoCEST MRI to assess treatment or physiological responses over time.

Indexed as

Chemical exchange saturation transfer (CEST)field inhomogeneityglycoCESTnavigatorreproducibilityshim correction

Identifiers

PMID31728311
PMCPMC6828578

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.