Evidence map›Paper›PMID 31728309›Full record

ArticleQuantitative imaging in medicine and surgery2019

Imaging of glutamate in acute traumatic brain injury using chemical exchange saturation transfer.

Yifei Mao, Zerui Zhuang, Yanzi Chen, Xiaolei Zhang, Yuanyu Shen, Guisen Lin, Renhua Wu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Clinical application ofFrontiers in neuroscience · 2026
    Article
  4. Article
  5. CEST MRI in the Management/Diagnosis of Neuroinfectious Diseases.International journal of molecular sciences · 2025
    Review
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  7. Review
  8. Article
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  11. Review
  12. Article
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  17. Article
  18. Review
  19. Pharmacological Intervention of Post-traumatic Seizure: Advanced Research Progress.Dose-response : a publication of International Hormesis Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yifei MaoDepartment of Medical Imaging, The Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Zerui ZhuangDepartment of Neurosurgery, The Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Yanzi ChenDepartment of Medical Imaging, The Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Xiaolei ZhangDepartment of Neurosurgery, The Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Yuanyu ShenDepartment of Medical Imaging, The Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Guisen LinDepartment of Medical Imaging, The Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Renhua WuDepartment of Medical Imaging, The Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Second Affiliated Hospital of Shantou University Medical College · CNShantou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChemical exchange saturation transfer (CEST) is an important contrast mechanism in the field of magnetic resonance imaging. Herein, we used CEST for glutamate (GluCEST) imaging to evaluate the Glu alterations in acute mild to moderate traumatic brain injury (TBI) and correlated such alterations with the cognitive outcome at 1-month postinjury.

methodsThirty-two patients with well-documented mild-to-moderate TBI and 15 healthy controls (HC group) underwent 3.0-Tesla magnetic resonance imaging (MRI) with GluCEST, and magnetic resonance spectroscopy (MRS) scans. The Montreal Cognitive Assessment (MoCA) examination was administered to all study subjects at 1-month postinjury for cognitive outcome acquisition and divided TBI patients into patients with good cognitive outcome (GCO group) and with poor cognitive outcome (PCO group).

resultsThe GluCEST% values for the occipital gray matter (OGM) and bilateral parietooccipital white matter (PWM) were higher in the PCO group compared with the HC and GCO groups (P<0.05), whereas the GluCEST% value showed no significant differences between the GCO and HC groups (P>0.05). In comparison with HCs, TBI patients had a significantly increased GluCEST% value for the OGM and bilateral PWM (P<0.05). GluCEST performed better than MRS in the prediction of cognitive outcome for TBI patients (P<0.05).

conclusionsGlu is significantly increased in acute TBI and strongly correlates with the cognitive outcome at 1month postinjury. GluCEST may supply new insight into TBI and help to improve the accuracy of short-term outcome prediction.

Indexed as

Chemical exchange saturation transfer (CEST)cognitive outcomeglutamate (Glu)traumatic brain injury (TBI)

Identifiers

PMID31728309
PMCPMC6828583
OpenAlexW2980498853

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.