ArticleQuantitative imaging in medicine and surgery2019
Amide proton transfer-weighted MRI for predicting histological grade of hepatocellular carcinoma: comparison with diffusion-weighted imaging.
Article in Quantitative imaging in medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Role of apparent diffusion coefficient (ADC) and MRI-derived parameters in identifying p53-abnormal subtypes of endometrial cancer.European journal of radiology open · 2026Article
- Amide proton transfer-weighted imaging in predicting aggressiveness of hepatocellular carcinoma: comparison with diffusion-weighted imaging.Quantitative imaging in medicine and surgery · 2026Article
- Human liver CEST imaging at 7 T: Impact ofMagnetic resonance in medicine · 2025Article
- 3-Tesla amide proton transfer-weighted imaging (APT-WI): elevated signal also in tumor mimics.European radiology · 2025Article
- Predictive Value of IDEAL-IQ and DWI Imaging Biomarkers for P53 Mutations in Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2025Article
- APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage.Hepatic oncology · 2024Article
- Image quality assessment and feasibility of three-dimensional amide proton transfer-weighted imaging for hepatocellular carcinoma.Quantitative imaging in medicine and surgery · 2024Article
- Added-value of 3D amide proton transfer MRI in assessing prognostic factors of cervical cancer: a comparative study with multiple model diffusion-weighted imaging.Quantitative imaging in medicine and surgery · 2023Article
- Whole-tumor amide proton transfer-weighted imaging histogram analysis to predict pathological extramural venous invasion in rectal adenocarcinoma: a preliminary study.European radiology · 2023Article
- An update on liver chemical exchange saturation transfer imaging with a focus on clinical translation.Quantitative imaging in medicine and surgery · 2023Article
- Clinical and imaging features preoperative evaluation of histological grade and microvascular infiltration of hepatocellular carcinoma.BMC gastroenterology · 2022Article
- A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging.International journal of molecular sciences · 2021Review
- Liver MRI with amide proton transfer imaging: feasibility and accuracy for the characterization of focal liver lesions.European radiology · 2021Article
- Amide Proton Transfer-Weighted MRI Might Help Distinguish Amnestic Mild Cognitive Impairment From a Normal Elderly Population.Frontiers in neurology · 2021Article
- A Reliable Prognostic Model for HCC Using Histological Grades and the Expression Levels of Related Genes.Journal of oncology · 2021Article
- Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla.Quantitative imaging in medicine and surgery · 2020Article
- Amide Proton Transfer Imaging vs Diffusion Kurtosis Imaging for Predicting Histological Grade of Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2020Article
- Comparative Study of Amide Proton Transfer Imaging and Intravoxel Incoherent Motion Imaging for Predicting Histologic Grade of Hepatocellular Carcinoma.Frontiers in oncology · 2020Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver, preoperative grading of HCC is of great clinical significance. Amide proton transfer-weighted (APTw) imaging, as a novel contrast mechanism in the field of molecular imaging, provided new diagnostic ideas for the grading of HCC.
methodsBetween May 2017 and April 2018, 32 consecutive patients with pathologically confirmed HCC were enrolled, including 19 high-grade HCCs and 13 low-grade HCCs. DWI and APTw scanning was performed on a 3T MRI scanner. Two observers drew regions of interest independently by referring to the axial T
resultsThere were significant differences between the APTw or ADC values for the high- and low-grade HCCs (P=0.034 and 0.010). Both APTw and DWI had good diagnostic performance in differentiating the high- from the low-grade HCCs, with areas under the curves of 0.814 and 0.745, respectively. Moderate correlations existed between APTw values and histological grades (r=0.534; P=0.002), as well as ADC values and histological grades (r=-0.417; P=0.018).
conclusionsThe APTw imaging is a useful imaging biomarker that complements DWI for the more accurate and comprehensive HCC characterization.
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