ArticleQuantitative imaging in medicine and surgery2019
Challenges in glucoCEST MR body imaging at 3 Tesla.
Article in Quantitative imaging in medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05614310 (Early Detection Of Alzheimer's Disease With GlucoCEST MRI), which is not on this map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection Of Alzheimer's Disease With GlucoCEST MRI: A Feasibility Study.
Who cites it
14 citing papers in PubMed.
- Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026Review
- Novel non‑metal‑based contrast agents for MR imaging: Emerging approaches and clinical perspectives (Review).International journal of oncology · 2025Review
- Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging.Insights into imaging · 2024Article
- Improved postprocessing of dynamic glucose-enhanced CEST MRI for imaging brain metastases at 3 T.European radiology experimental · 2023Article
- Glucose exchange parameters in a subset of physiological conditions.Physical chemistry chemical physics : PCCP · 2023Article
- What do we know about dynamic glucose-enhanced (DGE) MRI and how close is it to the clinics? Horizon 2020 GLINT consortium report.Magma (New York, N.Y.) · 2022Review
- GlucoCEST MRI for the Evaluation Response to Chemotherapeutic and Metabolic Treatments in a Murine Triple-Negative Breast Cancer: A Comparison with[Molecular imaging and biology · 2022Article
- Towards robust glucose chemical exchange saturation transfer imaging in humans at 3 T: Arterial input function measurements and the effects of infusion time.NMR in biomedicine · 2022Article
- In vitro and in vivo comparison of MRI chemical exchange saturation transfer (CEST) properties between native glucose and 3-O-Methyl-D-glucose in a murine tumor model.NMR in biomedicine · 2021Article
- Current emerging MRI tools for radionecrosis and pseudoprogression diagnosis.Current opinion in oncology · 2021Review
- A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging.International journal of molecular sciences · 2021Review
- Chemical exchange sensitive MRI of glucose uptake using xylose as a contrast agent.Magnetic resonance in medicine · 2021Article
- Emerging methods in radiology.Der Radiologe · 2020Review
- Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging.Frontiers in oncology · 2020Review
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
backgroundThe aim of this study was to translate dynamic glucose enhancement (DGE) body magnetic resonance imaging (MRI) based on the glucose chemical exchange saturation transfer (glucoCEST) signal to a 3 T clinical field strength.
methodsAn infusion protocol for intravenous (i.v.) glucose was optimised using a hyperglycaemic clamp to maximise the chances of detecting exchange-sensitive MRI signal. Numerical simulations were performed to define the optimum parameters for glucoCEST measurements with consideration to physiological conditions. DGE images were acquired for patients with lymphomas and prostate cancer injected i.v. with 20% glucose.
resultsThe optimised hyperglycaemic clamp infusion based on the DeFronzo method demonstrated higher efficiency and stability of glucose delivery as compared to manual determination of glucose infusion rates. DGE signal sensitivity was found to be dependent on T
conclusionsBased on our simulated and experimental results, we conclude that glucose-related signal remains elusive at 3 T in body regions, where physiological movements and strong effects of B
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.