Evidence map›Paper›PMID 31728306›Full record

ArticleQuantitative imaging in medicine and surgery2019

Preliminary evaluation of dynamic glucose enhanced MRI of the human placenta during glucose tolerance test.

Jie Luo, Esra Abaci Turk, Borjan Gagoski, Natalie Copeland, Iris Y Zhou, Vanessa Young, Carolina Bibbo, Julian N Robinson, Chloe Zera, William H Barth and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Jie LuoSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Esra Abaci TurkFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Borjan GagoskiFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Natalie CopelandFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Iris Y ZhouAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Vanessa YoungFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Carolina BibboDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.
Julian N RobinsonDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.
Chloe ZeraDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.
William H BarthDepartment of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA.
Drucilla J RobertsDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Phillip Zhe SunAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
P Ellen GrantFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Boston Children's Hospital · USBrigham and Women's Hospital · USMassachusetts General Hospital · USEmory University · US

Funding

Noninvasive Realtime Assessment of Placental Structure and Function with Novel MR Imaging MethodsU01HD087211 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI GRANT, PATRICIA ELLEN, WALD, LAWRENCE L · 2015 to 2015
$4.9M
NICHD NIH HHS U01 HD087211
6 · The paper itself

Abstract

backgroundTo investigate dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) MRI as a means to non-invasively image glucose transport in the human placenta.

methodsContinuous wave (CW) CEST MRI was performed at 3.0 Tesla. The glucose contrast enhancement (GCE) was calculated based on the magnetization transfer asymmetry (MTRasym), and the DGE was calculated with the positive side of Z-spectra in reference to the first time point. The glucose CEST (GlucoCEST) was optimized using a glucose solution phantom. Glucose solution perfused

resultsThe GCE effect peaks at a saturation B1 field of about 2 μT, and the GlucoCEST effect increases linearly with the glucose concentration between 4-20 mM. In

conclusionsDespite the challenges of placental motion and field inhomogeneity, our study demonstrated the feasibility of DGE placenta MRI at 3.0 Tesla.

Indexed as

Dynamic glucose enhancementglucose chemical exchange saturation transfer (GlucoCEST)MRIplacental function

Identifiers

PMID31728306
PMCPMC6828580
OpenAlexW2981584578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.