Evidence map›Paper›PMID 31728265›Full record

ArticleCurrent addiction reports2019

Dopamine and Gambling Disorder: Prospects for Personalized Treatment.

Andrew Kayser

Open access · greenAbstract read
In one paragraph

Article in Current addiction reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Attenuated Directed Exploration during Reinforcement Learning in Gambling Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Andrew KayserDepartment of Neurology, Weill Institute for Neurosciences, University of California at San Francisco.
University of California, San Francisco · US

Funding

Dopaminergic Mechanisms Underlying Human Social Behavior: A Multimodal ApproachR01MH112775 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HSU, MING, KAYSER, ANDREW S · 2019 to 2023
$3.5M
Behavioral and Neural Correlates of Social Function in Alcohol Use DisordersR01AA026587 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAYSER, ANDREW S · 2018 to 2022
$2.3M
NIAAA NIH HHS R01 AA026587NIMH NIH HHS R01 MH112775
6 · The paper itself

Abstract

purpose of reviewTo address variation in the severity of gambling disorder, this review evaluates the contribution of mesocorticolimbic dopamine neurons to potential behavioral endophenotypes, the influence of individual differences in the dopamine system on gambling and related behaviors, and the possible role for dopaminergic medications in the treatment of gambling disorder. RECENT

findingsNewer work has suggested that dopaminergic dysfunction can lead to increased reward anticipation and a greater sensitivity to uncertainty, which in turn may drive addictive gambling behaviors. In addition, increased impulsivity, a well-recognized risk factor for gambling disorder, has been linked to dopaminergic dysfunction. More recently, emerging evidence has suggested that dopaminergic medications can influence the discounting of delayed rewards. SUMMARY: Dopaminergic drugs that increase the salience of long-term over short-term goals may ameliorate symptoms of impulsive individuals with gambling disorder. More broadly, improved understanding of intermediate behavioral and other phenotypes with a defined neurobiological substrate may allow for personalized treatment of gambling disorder and other psychiatric conditions.

Indexed as

addictioncomputational psychiatrydelay discountingdopaminegamblingimpulsivity

Identifiers

PMID31728265
PMCPMC6855253
OpenAlexW2920945877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.