Evidence map›Paper›PMID 31728055›Full record

ArticleLeukemia2020

Opposing effects of NPM1wt and NPM1c mutants on AKT signaling in AML.

Zhuo Ren, Mariusz Shrestha, Takashi Sakamoto, Tali Melkman, Li Meng, Rob A Cairns, Eldad Zacksenhaus, Tak W Mak, Vuk Stambolic, Mark D Minden and 1 more

Abstract readCase ReportsLetter
PubMed Publisher
In one paragraph

Article in Leukemia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Mutant NPM1-Regulated FTO-Mediated mFrontiers in oncology · 2022
    Article
  6. Targeting Akt in cancer for precision therapy.Journal of hematology & oncology · 2021
    Review
  7. Article
  8. NPM1 Biology in Myeloid Neoplasia.Current hematologic malignancy reports · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Zhuo RenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Mariusz ShresthaToronto General Research Institute, University Health Network, Toronto, ON, Canada.
Takashi SakamotoThe Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Tali MelkmanPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Li MengPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Rob A CairnsThe Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Eldad ZacksenhausToronto General Research Institute, University Health Network, Toronto, ON, Canada.
Tak W MakPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Vuk StambolicPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Mark D MindenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. mark.minden@uhn.ca.
Jiance Atom WangPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-7230-7576
University Health Network · CA

Funding

CIHR
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutationAgedFemaleHumansLeukemia, Myeloid, AcuteNuclear ProteinsNucleophosminPhosphorylationProto-Oncogene Proteins c-aktSignal TransductionAKT1 protein, humanNPM1 protein, humanNuclear ProteinsNucleophosminProto-Oncogene Proteins c-aktAcute Myeloid Leukemia (AML)AKT SignalingNPM1c MutationNucleophosmin (NPM1)Physical Interaction

Identifiers

PMID31728055
OpenAlexW2987205136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.