ArticleScientific reports2019
TmDorX2 positively regulates antimicrobial peptides in Tenebrio molitor gut, fat body, and hemocytes in response to bacterial and fungal infection.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Tissue- and time-dependent modulation of JAK/STAT pathway genes in Tenebrio molitor during Listeria monocytogenes infection.World journal of microbiology & biotechnology · 2026Article
- A possible role of Painless channel in the regulation of immune system activity in Tenebrio molitor L.Scientific reports · 2026Article
- The immune response of Phytoseiulus persimilis (Acari: Phytoseiidae) to the bacterial pathogen Acaricomes phytoseiuli.Experimental & applied acarology · 2025Article
- Effects of TmTak1 silencing on AMP production as an Imd pathway component in Tenebrio molitor.Scientific reports · 2023Article
- Impact of the Diet on the Mortality and on Gene Expression of the Antimicrobial Peptide Tenecin 3 inInsects · 2023Article
- Innate Immune Response ofInternational journal of molecular sciences · 2023Article
- Recent trends in insect gut immunity.Frontiers in immunology · 2023Review
- Available for millions of years but discovered through the last decade: Insects as a source of nutrients and energy in animal diets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Immunological Roles ofInternational journal of molecular sciences · 2022Article
- Emerging Evidence onMicroorganisms · 2022Review
- Transgenic Silkworms Overexpressing Relish and Expressing Drosomycin Confer Enhanced Immunity to Multiple Pathogens.Molecular biotechnology · 2022Article
- Potential of Antimicrobial Peptide-OverexpressedInsects · 2022Article
- Article
- Article
- Autophagy inFrontiers in immunology · 2021Review
- Critical Roles of Spätzle5 in Antimicrobial Peptide Production AgainstFrontiers in immunology · 2021Article
- Article
- Blattella germanica displays a large arsenal of antimicrobial peptide genes.Scientific reports · 2020Article
- IKKγ/NEMO Is Required to Confer Antimicrobial Innate Immune Responses in the Yellow Mealworm,International journal of molecular sciences · 2020Article
- Biosurfactants Induce Antimicrobial Peptide Production through the Activation ofInternational journal of molecular sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dorsal, a member of the nuclear factor-kappa B (NF-κB) family of transcription factors, is a critical downstream component of the Toll pathway that regulates the expression of antimicrobial peptides (AMPs) against pathogen invasion. In this study, the full-length ORF of Dorsal was identified from the RNA-seq database of the mealworm beetle Tenebrio molitor (TmDorX2). The ORF of TmDorX2 was 1,482 bp in length, encoding a polypeptide of 493 amino acid residues. TmDorX2 contains a conserved Rel homology domain (RHD) and an immunoglobulin-like, plexins, and transcription factors (IPT) domain. TmDorX2 mRNA was detected in all developmental stages, with the highest levels observed in 3-day-old adults. TmDorX2 transcripts were highly expressed in the adult Malpighian tubules (MT) and the larval fat body and MT tissues. After challenging the larvae with Staphylococcus aureus and Escherichia coli, the TmDorX2 mRNA levels were upregulated 6 and 9 h post infection in the whole body, fat body, and hemocytes. Upon Candida albicans challenge, the TmDorX2 mRNA expression were found highest at 9 h post-infection in the fat body. In addition, TmDorX2-knockdown larvae exposed to E. coli, S. aureus, or C. albicans challenge showed a significantly increased mortality rate. Furthermore, the expression of 11 AMP genes was downregulated in the gut and fat body of dsTmDorX2-injected larvae upon E. coli challenge. After C. albicans and S. aureus challenge of dsTmDorX2-injected larvae, the expression of 11 and 10 AMPs was downregulated in the gut and fat body, respectively. Intriguingly, the expression of antifungal transcripts TmTenecin-3 and TmThaumatin-like protein-1 and -2 was greatly decreased in TmDorX2-silenced larvae in response to C. albicans challenge, suggesting that TmDorX2 regulates antifungal AMPs in the gut in response to C. albicans infection. The AMP expression profiles in the fat body, hemocytes, gut, and MTs suggest that TmDorX2 might have an important role in promoting the survival of T. molitor larvae against all mentioned pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.