ArticleScientific reports2019
A novel mouse model for septic arthritis induced by Pseudomonas aeruginosa.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Comparison ofInfection and immunity · 2026Article
- Barbados aloe as a water-administered therapeutic against Pseudomonas aeruginosa infection in Clarias gariepinus: Effects on hemato-biochemical profiles, electrolyte homeostasis, antioxidant capacity, and tissue histology.Veterinary research communications · 2026Article
- Comparison ofbioRxiv : the preprint server for biology · 2026Article
- Bacterial and host interactions inFrontiers in microbiology · 2025Review
- Synergic effect of combined xenogeneic mesenchymal stem cells and ceftriaxone on acute septic arthritis.Stem cells translational medicine · 2024Article
- Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies.Frontiers in microbiology · 2024Review
- Review
- Commensal Bacteria AugmentFrontiers in cellular and infection microbiology · 2022Article
- An Organ System-Based Synopsis ofVirulence · 2021Review
- Bacteria and Host Interplay inPathogens (Basel, Switzerland) · 2021Review
- Biofilm Formation byFrontiers in cellular and infection microbiology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Septic arthritis is one of the most aggressive joint diseases. Although caused predominantly by S. aureus, Gram-negative bacteria, Pseudomonas aeruginosa among them, account for a significant percentage of the causal agents of septic arthritis. However, septic arthritis caused by P. aeruginosa has not been studied thus far, due to lack of an animal model. NMRI mice were inoculated with different doses of P. aeruginosa. The clinical course of septic arthritis and radiological changes of joints were examined. Furthermore, the host molecular and cellular mechanisms involved in P. aeruginosa-induced septic arthritis were investigated. Inoculation of mice with P. aeruginosa caused septic arthritis in a dose-dependent manner. Neutrophil depletion led to higher mortality and more severe joint destruction (p < 0.01). In contrast, monocyte depletion resulted in higher mortality (p < 0.05) but similar arthritis severity compared to controls. Mice depleted of CD4+ T-cells inoculated with P. aeruginosa displayed less severe bone damage (p < 0.05). For the first time, a mouse model for P. aeruginosa septic arthritis is presented. Our data demonstrate that neutrophils play a protective role in P. aeruginosa septic arthritis. Monocytes/macrophages, on the other hand, are only essential in preventing P. aeruginosa-induced mortality. Finally, CD4+ T-cells are pathogenic in P. aeruginosa septic arthritis.
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