Evidence map›Paper›PMID 31727908›Full record

ArticleScientific reports2019

Multiple genome analyses reveal key genes in Vitamin C and Vitamin D synthesis and transport pathways are shared.

Wei Dong, Cheng Tian, Yan Jiao, Savannah Blackwell, Ge Lou, Arnold Postlethwaite, Weikuan Gu, Dianjun Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Vitamin C and Cardiovascular Disease: An Update.Antioxidants (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Wei DongDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center (UTHSC), 956 Court Av, Memphis, TN, 38163, USA.
Cheng TianDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center (UTHSC), 956 Court Av, Memphis, TN, 38163, USA.
Yan JiaoDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center (UTHSC), 956 Court Av, Memphis, TN, 38163, USA.
Savannah BlackwellDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center (UTHSC), 956 Court Av, Memphis, TN, 38163, USA.
Ge LouDepartment of Gynecology, Harbin Medical University Cancer Hospital, Haping Road, Harbin, Heilongjiang, 150081, China.
Arnold PostlethwaiteDepartment of Medicine, University of Tennessee Health Science Center (UTHSC), 956 Court Av, Memphis, TN, 38163, USA.
Weikuan GuDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center (UTHSC), 956 Court Av, Memphis, TN, 38163, USA. wgu@uthsc.edu.
Dianjun SunCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University; Key Laboratory of Etiologic Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618104), 157 Baojian Road, Harbin, Heilongjiang, 150081, China. hrbmusdj@163.com.
University of Tennessee Health Science Center · USChinese Center For Disease Control and Prevention · CNHarbin Medical University · CNThird Affiliated Hospital of Harbin Medical University · CNVeterans Health Administration · US

Funding

BLRD VA I01 BX000671
6 · The paper itself

Abstract

Vitamin C (VC) and vitamin D (VD) have been widely used as the dietary supplements and in treatment of diseases both independently and in combination. Whether there is a connection between their pathways is critical for their therapeutic applications. Using whole-genome expression profiles, we performed multiple measures of associations, networks, eQTL mappings and expressions of key genes of interest in VC and VD functions. Several key genes in their pathways were found to be associated. Gc and Rgn play important roles connecting VC and VD pathways in mice. The r values of expression levels between Gc and Rgn in mouse spleen, liver, lung, and kidney are 0.937, 0.558, 0.901, and 0.617, respectively. The expression QTLs of Gc and Rgn are mapped onto the same locations, i.e., 68-76 MB in chromosome 7 and 26-36 MB in chromosome 9. In humans, there are positive correlations between CYP27B1 and SLC23A1 expression levels in kidney (r = 0.733) and spleen (r = 0.424). SLC23A2 and RXRA are minimally associated in both mouse and human. These data indicate that pathways of VC and VD are not independent but affect each other, and this effect is different between mice and humans during VC and VD synthesis and transportation.

Indexed as

Gene Regulatory NetworksQuantitative Trait LociAnimalsAscorbic AcidBiological TransportCalcium-Binding ProteinsChromosome MappingChromosomes, Human, Pair 7Chromosomes, Human, Pair 9Exome SequencingGene Expression ProfilingGene Expression RegulationHumansIntracellular Signaling Peptides and ProteinsKidneyLiverAscorbic AcidCalcium-Binding ProteinsGC protein, humanIntracellular Signaling Peptides and ProteinsRGN protein, humanVitamin DVitamin D-Binding Protein

Identifiers

PMID31727908
PMCPMC6856197
OpenAlexW2984379148

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.