ArticleScientific reports2019
Piezo1 channel activation mimics high glucose as a stimulator of insulin release.
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Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
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Who cites it
34 citing papers in PubMed, 54 citations in OpenAlex.
- PIEZO Channels in Metabolism and Metabolic Diseases: Research Advances and Therapeutic Strategies.Current obesity reports · 2026Review
- Systematic Expression and Localization Profiling of Piezo2 in Rodent Pancreatic Islets.Nutrients · 2026Article
- Mechanostimulation of neuroendocrine cells and their clinical relevance.Molecular and cellular biochemistry · 2026Review
- PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy of diabetic neuropathy.Molecular biology reports · 2025Review
- Mechanosensitive Channels Mediate Pancreatic β Cells Reactive Oxygen Species Formation and Downregulation of Essential Genes During Therapeutic Ultrasound Treatment.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
- Osmosensor TMEM63B facilitates insulin secretion in pancreatic β-cells.Science China. Life sciences · 2025Article
- SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling.Communications biology · 2025Article
- Increased expression levels of PIEZO1 in visceral adipose tissue in obesity and type 2 diabetes are triggered by mechanical forces and are associated with inflammation.Molecular medicine (Cambridge, Mass.) · 2024Article
- Pharmacology of PIEZO1 channels.British journal of pharmacology · 2024Review
- Article
- Chemical mapping of the surface interactome of PIEZO1 identifies CADM1 as a modulator of channel inactivation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Piezo1, the new actor in cell volume regulation.Pflugers Archiv : European journal of physiology · 2024Review
- Extracellular matrix stiffness mediates insulin secretion in pancreatic islets via mechanosensitive Piezo1 channel regulated CaMatrix biology plus · 2024Article
- A static glucose-stimulated insulin secretion (sGSIS) assay that is significantly predictive of time to diabetes reversal in the human islet bioassay.BMJ open diabetes research & care · 2024Article
- Differential sensitivity to longitudinal and transverse stretch mediates transcriptional responses in mouse neonatal ventricular myocytes.American journal of physiology. Heart and circulatory physiology · 2024Article
- Mechanosensitive Cation Channel Piezo1 Is Involved in Renal Fibrosis Induction.International journal of molecular sciences · 2024Review
- [Hot Topics and Emerging Trends in Mechanobiology Research].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Hypertonicity during a rapid rise in D-glucose mediates first-phase insulin secretion.Frontiers in endocrinology · 2024Article
- Mechanosensing in Metabolism.Comprehensive Physiology · 2023Review
- Transcriptomic profile of the mechanosensitive ion channelome in human cardiac fibroblasts.Experimental biology and medicine (Maywood, N.J.) · 2023Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Vijayalakshmi DeivasikamaniLeeds Institute for Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Savitha DhayalanLeeds Institute for Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Yilizila AbudushalamuLeeds Institute for Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Romana MughalLeeds Institute for Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Asjad VisnagriLeeds Institute for Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Kevin CuthbertsonSchool of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Jason L ScraggLeeds Institute for Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Tim S MunseySchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Hema ViswambharanLeeds Institute for Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Katsuhiko MurakiSchool of Pharmacy, Aichi-Gakuin University, 1-100 Kusumoto, Chikusa, Nagoya, 464-8650, Japan.
Richard FosterSchool of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Asipu SivaprasadaraoSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Mark T KearneyLeeds Institute for Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom.
David J BeechLeeds Institute for Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom.ORCID http://orcid.org/0000-0002-7683-9422
Piruthivi SukumarLeeds Institute for Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom. P.Sukumar@leeds.ac.uk.ORCID http://orcid.org/0000-0002-3294-989X
University of Leeds · GBAichi Gakuin University · JP
Funding
British Heart Foundation CH/13/1/30086British Heart Foundation PG/14/54/30939British Heart Foundation PG/17/16/32853British Heart Foundation RG/15/7/31521British Heart Foundation RG/17/11/33042British Heart Foundation (BHF) PG/17/16/32853Wellcome Trust 110044/Z/15/Z
Abstract
Glucose and hypotonicity induced cell swelling stimulate insulin release from pancreatic β-cells but the mechanisms are poorly understood. Recently, Piezo1 was identified as a mechanically-activated nonselective Ca
Indexed as
AnimalsBiological TransportCalciumCell Line, TumorGadoliniumGene Expression RegulationGlucoseHeterozygoteInsulinInsulin-Secreting CellsInsulin SecretionIon ChannelsMechanotransduction, CellularMembrane ProteinsMiceMice, Inbred C57BLCalciumGadoliniumGlucoseInsulinIon ChannelsMembrane ProteinsPiezo1 protein, mousePiezo1 protein, ratPyrazinesRNA, Small InterferingRuthenium RedThiadiazolesyoda-1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.