Evidence map›Paper›PMID 31727854›Full record

ArticleDisease models & mechanisms2019

A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress.

Alberto Rissone, Erin Jimenez, Kevin Bishop, Blake Carrington, Claire Slevin, Stephen M Wincovitch, Raman Sood, Fabio Candotti, Shawn M Burgess

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis.Biochemical and biophysical research communications · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alberto RissoneTranslational and Functional Genomics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD, USA.
Erin JimenezTranslational and Functional Genomics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD, USA.
Kevin BishopNHGRI Zebrafish Core, Translational and Functional Genomics Branch, NHGRI, NIH, Bethesda, MD, USA.
Blake CarringtonNHGRI Zebrafish Core, Translational and Functional Genomics Branch, NHGRI, NIH, Bethesda, MD, USA.
Claire SlevinTranslational and Functional Genomics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD, USA.
Stephen M WincovitchNHGRI Cytogenetics and Microscopy Core, NHGRI, NIH, Bethesda, MD, USA.
Raman SoodTranslational and Functional Genomics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD, USA.
Fabio CandottiDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-6399-6042
Shawn M BurgessTranslational and Functional Genomics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD, USA burgess@mail.nih.gov.ORCID 0000-0003-1147-0596
National Institutes of Health · USNational Human Genome Research Institute · USUniversity of Lausanne · CH

Funding

Zebrafish targeted mutagenesis and functional genomicsZIAHG000183 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BURGESS, SHAWN M · 2009 to 2025
$16.7M
Intramural NIH HHS ZIA HG000183NHGRI NIH HHS ZIA HG000183
6 · The paper itself

Abstract

Mutations in the gene

Indexed as

Gene Expression Regulation, DevelopmentalRegenerationAdenylate KinaseAllelesAnimalsAnimals, Genetically ModifiedCell DeathCell LineCrosses, GeneticDisease Models, AnimalGlutathioneGreen Fluorescent ProteinsHair Cells, AuditoryHearing Loss, SensorineuralHematopoietic Stem Cell TransplantationLeukopeniaAdenylate Kinaseadenylate kinase 2GlutathioneGreen Fluorescent ProteinsAk2AntioxidantsHair cellsHearing lossLateral lineReticular dysgenesisSCIDZebrafish

Identifiers

PMID31727854
PMCPMC6955229
OpenAlexW2983515040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.