ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Dopamine-Dependent Loss Aversion during Effort-Based Decision-Making.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Microstimulation of the human dopaminergic midbrain enhances outcome-related happiness and reduces loss seeking.bioRxiv : the preprint server for biology · 2026Article
- When effort fuels risk: Cognitive exertion increases risk-taking for gains but reduces it for losses.Cognitive, affective & behavioral neuroscience · 2026Article
- Predicting substance use behaviors with machine learning using small sets of judgment and contextual variables.Npj mental health research · 2026Article
- Day-to-day fluctuations in motivation drive effort-based decision-making.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cognitive effort devaluation and the salience network: a computational model of amotivation in depression.Frontiers in psychiatry · 2025Article
- The influence of reward and loss outcomes after free- and forced-tasks on voluntary task choice.Psychological research · 2024Article
- A novel approach to anxiety level prediction using small sets of judgment and survey variables.Npj mental health research · 2024Article
- Acute stress promotes effort mobilization for safety-related goals.Communications psychology · 2024Article
- Predicting COVID-19 Vaccination Uptake Using a Small and Interpretable Set of Judgment and Demographic Variables: Cross-Sectional Cognitive Science Study.JMIR public health and surveillance · 2024Article
- Dopamine Increases Accuracy and Lengthens Deliberation Time in Explicit Motor Skill Learning.eNeuro · 2024Article
- Bilateral arm movements are coordinated via task-dependent negotiations between independent and codependent control, but not by a "coupling" control policy.Journal of neurophysiology · 2023Article
- Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control.Frontiers in behavioral neuroscience · 2023Article
- High-definition transcranial direct current stimulation of the dorsal anterior cingulate cortex modulates decision-making and executive control.Brain structure & function · 2022Article
- How Can Animal Models Inform the Understanding of Cognitive Inflexibility in Patients with Anorexia Nervosa?Journal of clinical medicine · 2022Review
- Decision neuroscience and neuroeconomics: Recent progress and ongoing challenges.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- Local and distributed cortical markers of effort expenditure during sustained goal pursuit.NeuroImage · 2021Article
- Aging Increases Prosocial Motivation for Effort.Psychological science · 2021Article
- Reward-Based Improvements in Motor Control Are Driven by Multiple Error-Reducing Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Commentary: Dopamine-Dependent Loss Aversion during Effort-Based Decision-Making.Frontiers in neuroscience · 2020Article
- Losses Motivate Cognitive Effort More Than Gains in Effort-Based Decision Making and Performance.Frontiers in human neuroscience · 2020Article
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From psychology to economics, there has been substantial interest in how costs (e.g., delay, risk) are represented asymmetrically during decision-making when attempting to gain reward or avoid punishment. For example, in decision-making under risk, individuals show a tendency to prefer to avoid punishment rather than to acquire the equivalent reward (loss aversion). Although the cost of physical effort has recently received significant attention, it remains unclear whether loss aversion exists during effort-based decision-making. On the one hand, loss aversion may be hardwired due to asymmetric evolutionary pressure on losses and gains and therefore exists across decision-making contexts. On the other hand, distinct brain regions are involved with different decision costs, making it questionable whether similar asymmetries exist. Here, we demonstrate that young healthy human participants (females, 16; males, 6) exhibit loss aversion during effort-based decision-making by exerting more physical effort to avoid punishment than to gain a same-size reward. Next, we show that medicated Parkinson's disease (PD) patients (females, 9; males, 9) show a reduction in loss aversion compared with age-matched control subjects (females, 11; males, 9). Behavioral and computational analysis revealed that people with PD exerted similar physical effort in return for a reward but were less willing to produce effort to avoid punishment. Therefore, loss aversion is present during effort-based decision-making and can be modulated by altered dopaminergic state. This finding could have important implications for our understanding of clinical disorders that show a reduced willingness to exert effort in the pursuit of reward.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.