Evidence map›Paper›PMID 31727794›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

The Emergence of a Stable Neuronal Ensemble from a Wider Pool of Activated Neurons in the Dorsal Medial Prefrontal Cortex during Appetitive Learning in Mice.

Leonie S Brebner, Joseph J Ziminski, Gabriella Margetts-Smith, Meike C Sieburg, Hayley M Reeve, Thomas Nowotny, Johannes Hirrlinger, Tristan G Heintz, Leon Lagnado, Shigeki Kato and 5 more

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Refinement of Nucleus Accumbens Neuronal Dynamics during Cocaine Self-Administration Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Distinct prelimbic cortex ensembles encode response execution and inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Prelimbic cortical excitatory overdrive and inhibitory underdrive accompany environmental suppression of food seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  7. To indulge or enrich: how environmental enrichment affects neurons that promote food seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Differential genetic expression within reward-specific ensembles in mice.bioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Formation and fate of an engram in the lateral amygdala supporting a rewarding memory in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. FosGFP expression does not capture a sensory learning-related engram in superficial layers of mouse barrel cortex.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Inactivation of the infralimbic cortex decreases discriminative stimulus-controlled relapse to cocaine seeking in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Leonie S BrebnerSussex Neuroscience, School of Psychology, University of Sussex, Falmer, BN1 9QG, United Kingdom.ORCID 0000-0002-4540-2826
Joseph J ZiminskiSussex Neuroscience, School of Psychology, University of Sussex, Falmer, BN1 9QG, United Kingdom.ORCID 0000-0003-4286-6868
Gabriella Margetts-SmithSussex Neuroscience, School of Psychology, University of Sussex, Falmer, BN1 9QG, United Kingdom.ORCID 0000-0002-1885-2661
Meike C SieburgSussex Neuroscience, School of Psychology, University of Sussex, Falmer, BN1 9QG, United Kingdom.ORCID 0000-0002-7095-3371
Hayley M ReeveSussex Neuroscience, School of Psychology, University of Sussex, Falmer, BN1 9QG, United Kingdom.ORCID 0000-0002-1598-6613
Thomas NowotnySussex Neuroscience, School of Engineering and Informatics, University of Sussex, Falmer, BN1 9QJ, United Kingdom.ORCID 0000-0002-4451-915X
Johannes HirrlingerCarl-Ludwig-Institute for Physiology, University of Leipzig, D-04103, Leipzig, Germany, and Department of Neurogenetics, Max-Planck-Institute for Experimental Medicine, D-37075, Göttingen, Germany.ORCID 0000-0002-6327-0089
Tristan G HeintzSussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, United Kingdom.
Leon LagnadoSussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, United Kingdom.
Shigeki KatoDepartment of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan, and.ORCID 0000-0002-8792-7591
Kazuto KobayashiDepartment of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan, and.ORCID 0000-0002-7617-2939
Leslie A RamseyBehavioral Neuroscience Branch, Intramural Research Program/National Institute on Drug Abuse/National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland 21224.ORCID 0000-0001-8129-612X
Catherine N HallSussex Neuroscience, School of Psychology, University of Sussex, Falmer, BN1 9QG, United Kingdom.ORCID 0000-0002-2316-7714
Hans S CrombagSussex Neuroscience, School of Psychology, University of Sussex, Falmer, BN1 9QG, United Kingdom.ORCID 0000-0002-0052-7836
Eisuke KoyaSussex Neuroscience, School of Psychology, University of Sussex, Falmer, BN1 9QG, United Kingdom, e.koya@sussex.ac.uk.ORCID 0000-0002-5039-4875

Funding

Biotechnology and Biological Sciences Research Council BB/M009017/1Medical Research Council MR/S026495/1Medical Research Council MR/V036750/1
6 · The paper itself

Abstract

Animals selectively respond to environmental cues associated with food reward to optimize nutrient intake. Such appetitive conditioned stimulus-unconditioned stimulus (CS-US) associations are thought to be encoded in select, stable neuronal populations or neuronal ensembles, which undergo physiological modifications during appetitive conditioning. These ensembles in the medial prefrontal cortex (mPFC) control well-established, cue-evoked food seeking, but the mechanisms involved in the genesis of these ensembles are unclear. Here, we used male

Indexed as

AnimalsAppetitive BehaviorConditioning, ClassicalCuesMaleMental RecallMiceMice, TransgenicNeuronal PlasticityNeuronsPrefrontal Cortexappetitive conditioningfood seekingFosin vivo imagingmedial prefrontal cortexneuronal ensembles

Identifiers

PMID31727794
PMCPMC6948940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.