ArticleGenes & development2019
Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity.
Article in Genes & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice.Nature communications · 2026Article
- Weight Loss-Associated Remodeling of Adipose Tissue Immunometabolism.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Unraveling the complexities of diet induced obesity and glucolipid dysfunction in metabolic syndrome.Diabetology & metabolic syndrome · 2025Review
- Immune Regulatory Crosstalk in Adipose Tissue Thermogenesis.Comprehensive Physiology · 2025Review
- Isolation of Exosome from Senescent Preadipocytes for Mass Spectrometric Analysis.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates.Nature communications · 2024Article
- Immune cells in adipose tissue microenvironment under physiological and obese conditions.Endocrine · 2024Review
- Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice.Nature communications · 2023Article
- Physiological and pathological roles of lipogenesis.Nature metabolism · 2023Review
- Adipose tissue aging is regulated by an altered immune system.Frontiers in immunology · 2023Review
- Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation.Nature metabolism · 2022Article
- Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes.Molecular medicine (Cambridge, Mass.) · 2022Article
- Immune and non-immune functions of adipose tissue leukocytes.Nature reviews. Immunology · 2022Review
- Metabolic and immunological phenotype of rare lipomatoses: Dercum's disease and Roch-Leri mesosomatic lipomatosis.Orphanet journal of rare diseases · 2021Article
- Innate Immune System Orchestrates Metabolic Homeostasis and Dysfunction in Visceral Adipose Tissue During Obesity.Frontiers in immunology · 2021Review
- Senescent T Cell Induces Brown Adipose Tissue "Whitening"Frontiers in cell and developmental biology · 2021Article
- Metabolism in Invariant Natural Killer T Cells: An Overview.Immunometabolism · 2021Article
- Obesity and CD8 T cell metabolism: Implications for anti-tumor immunity and cancer immunotherapy outcomes.Immunological reviews · 2020Review
- Adipocytes Are the Control Tower That Manages Adipose Tissue Immunity by Regulating Lipid Metabolism.Frontiers in immunology · 2020Review
- Two Faces of White Adipose Tissue with Heterogeneous Adipogenic Progenitors.Diabetes & metabolism journal · 2019Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In obesity, adipose tissue undergoes dynamic remodeling processes such as adipocyte hypertrophy, hypoxia, immune responses, and adipocyte death. However, whether and how invariant natural killer T (iNKT) cells contribute to adipose tissue remodeling are elusive. In this study, we demonstrate that iNKT cells remove unhealthy adipocytes and stimulate the differentiation of healthy adipocytes. In obese adipose tissue, iNKT cells were abundantly found nearby dead adipocytes. FasL-positive adipose iNKT cells exerted cytotoxic effects to eliminate hypertrophic and pro-inflammatory Fas-positive adipocytes. Furthermore, in vivo adipocyte-lineage tracing mice model showed that activation of iNKT cells by alpha-galactosylceramide promoted adipocyte turnover, eventually leading to potentiation of the insulin-dependent glucose uptake ability in adipose tissue. Collectively, our data propose a novel role of adipose iNKT cells in the regulation of adipocyte turnover in obesity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.